Publication Date:
1999-03-12
Description:
A selective advantage against infectious disease associated with increased heterozygosity at the human major histocompatibility complex [human leukocyte antigen (HLA) class I and class II] is believed to play a major role in maintaining the extraordinary allelic diversity of these genes. Maximum HLA heterozygosity of class I loci (A, B, and C) delayed acquired immunodeficiency syndrome (AIDS) onset among patients infected with human immunodeficiency virus-type 1 (HIV-1), whereas individuals who were homozygous for one or more loci progressed rapidly to AIDS and death. The HLA class I alleles B*35 and Cw*04 were consistently associated with rapid development of AIDS-defining conditions in Caucasians. The extended survival of 28 to 40 percent of HIV-1-infected Caucasian patients who avoided AIDS for ten or more years can be attributed to their being fully heterozygous at HLA class I loci, to their lacking the AIDS-associated alleles B*35 and Cw*04, or to both.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carrington, M -- Nelson, G W -- Martin, M P -- Kissner, T -- Vlahov, D -- Goedert, J J -- Kaslow, R -- Buchbinder, S -- Hoots, K -- O'Brien, S J -- N01-CO-56000/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1999 Mar 12;283(5408):1748-52.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Intramural Research Support Program, Science Applications International Corporation Frederick, National Cancer Institute (NCI), Frederick, MD 21702-1201, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10073943" target="_blank"〉PubMed〈/a〉
Keywords:
Acquired Immunodeficiency Syndrome/genetics/*immunology
;
Adult
;
Alleles
;
Antigen Presentation
;
Cohort Studies
;
Disease Progression
;
Ethnic Groups
;
*Genes, MHC Class I
;
Genetic Predisposition to Disease
;
HIV Infections/genetics/*immunology
;
HIV Long-Term Survivors/statistics & numerical data
;
*Hiv-1
;
HLA Antigens/genetics
;
HLA-B Antigens/*genetics
;
HLA-C Antigens/*genetics
;
Heterozygote
;
Homozygote
;
Humans
;
Killer Cells, Natural/immunology
;
Loss of Heterozygosity
;
Proportional Hazards Models
;
Risk
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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