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  • 1
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 1991-04-19
    Description: Inositol 1,4,5-trisphosphate (IP3)-induced calcium release from intracellular stores is a regulator of cytosolic-free calcium levels. The subsecond kinetics and regulation of IP3-induced calcium-45 release from synaptosome-derived microsomal vesicles were resolved by rapid superfusion. Extravesicular calcium acted as a coagonist, potentiating the transient IP3-induced release of calcium-45. Thus, rapid elevation of cytosolic calcium levels may trigger IP3-induced calcium release in vivo. Extravesicular calcium also produced a more slowly developing, reversible inhibition of IP3-induced calcium-45 release. Sequential positive and negative feedback regulation by calcium of IP3-induced calcium release may contribute to transients and oscillations of cytosolic-free calcium in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Finch, E A -- Turner, T J -- Goldin, S M -- GM35423/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1991 Apr 19;252(5004):443-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Harvard Medical School, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2017683" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/pharmacology ; Animals ; Brain/ultrastructure ; Calcimycin/pharmacology ; Calcium/*metabolism/pharmacology ; Calcium Radioisotopes ; Cytosol/metabolism ; Drug Synergism ; Heparin/pharmacology ; Inositol 1,4,5-Trisphosphate/*pharmacology ; Kinetics ; Magnesium/pharmacology ; Microsomes/drug effects/metabolism ; Rats ; Synaptosomes/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 1994-11-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dunlap, K -- Luebke, J I -- Turner, T J -- New York, N.Y. -- Science. 1994 Nov 4;266(5186):828-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7973643" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/metabolism ; Calcium Channel Blockers/*pharmacology ; Calcium Channels/drug effects/*physiology ; Hippocampus/drug effects/*physiology ; In Vitro Techniques ; *Neurosecretion/drug effects ; Peptides/pharmacology ; Rats ; Spider Venoms/pharmacology ; Synaptic Transmission/drug effects/*physiology ; omega-Agatoxin IVA ; *omega-Conotoxins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 1992-10-09
    Description: Presynaptic calcium channels are crucial elements of neuronal excitation-secretion coupling. In mammalian brain, they have been difficult to characterize because most presynaptic terminals are too small to probe with electrodes, and available pharmacological tools such as dihydropyridines and omega-conotoxin are largely ineffective. Subsecond measurements of synaptosomal glutamate release have now been used to assess presynaptic calcium channel activity in order to study the action of peptide toxins from the venom of the funnel web spider Agelenopsis aperta, which is known to inhibit dihydropyridine and omega-conotoxin-resistant neuronal calcium currents. A presynaptic calcium channel important in glutamate release is shown to be omega-Aga-IVA sensitive and omega-conotoxin resistant.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Turner, T J -- Adams, M E -- Dunlap, K -- New York, N.Y. -- Science. 1992 Oct 9;258(5080):310-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, Tufts University School of Medicine, Boston, MA 02111.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1357749" target="_blank"〉PubMed〈/a〉
    Keywords: Agatoxins ; Animals ; Batrachotoxins/pharmacology ; Brain/physiology/ultrastructure ; Calcium/pharmacology ; Calcium Channels/*physiology ; Egtazic Acid/pharmacology ; Frontal Lobe/ultrastructure ; Glutamates/*secretion ; Glutamic Acid ; Kinetics ; Mollusk Venoms/pharmacology ; Potassium Chloride/pharmacology ; Rats ; Spider Venoms/*pharmacology ; Synaptosomes/physiology ; omega-Agatoxin IVA ; omega-Conotoxin GVIA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2015-02-24
    Description: The evolution of galaxies is connected to the growth of supermassive black holes in their centers. During the quasar phase, a huge luminosity is released as matter falls onto the black hole, and radiation-driven winds can transfer most of this energy back to the host galaxy. Over five different epochs, we detected the signatures of a nearly spherical stream of highly ionized gas in the broadband x-ray spectra of the luminous quasar PDS 456. This persistent wind is expelled at relativistic speeds from the inner accretion disk, and its wide aperture suggests an effective coupling with the ambient gas. The outflow's kinetic power larger than 10(46) ergs per second is enough to provide the feedback required by models of black hole and host galaxy coevolution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nardini, E -- Reeves, J N -- Gofford, J -- Harrison, F A -- Risaliti, G -- Braito, V -- Costa, M T -- Matzeu, G A -- Walton, D J -- Behar, E -- Boggs, S E -- Christensen, F E -- Craig, W W -- Hailey, C J -- Matt, G -- Miller, J M -- O'Brien, P T -- Stern, D -- Turner, T J -- Ward, M J -- New York, N.Y. -- Science. 2015 Feb 20;347(6224):860-3. doi: 10.1126/science.1259202.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Astrophysics Group, School of Physical and Geographical Sciences, Keele University, Keele, Staffordshire ST5 5BG, UK. e.nardini@keele.ac.uk. ; Astrophysics Group, School of Physical and Geographical Sciences, Keele University, Keele, Staffordshire ST5 5BG, UK. Center for Space Science and Technology, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA. ; Cahill Center for Astronomy and Astrophysics, California Institute of Technology, Pasadena, CA 91125, USA. ; Istituto Nazionale di Astrofisica, Osservatorio Astrofisico di Arcetri, Largo Enrico Fermi 5, I-50125 Firenze, Italy. Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138, USA. ; INAF, Osservatorio Astronomico di Brera, Via Bianchi 46, I-23807 Merate (LC), Italy. ; Astrophysics Group, School of Physical and Geographical Sciences, Keele University, Keele, Staffordshire ST5 5BG, UK. ; Cahill Center for Astronomy and Astrophysics, California Institute of Technology, Pasadena, CA 91125, USA. Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA. ; Department of Physics, Technion, Haifa 32000, Israel. ; Space Science Laboratory, University of California, Berkeley, CA 94720, USA. ; Danmarks Tekniske Universitet Space-National Space Institute, Technical University of Denmark, Elektrovej 327, 2800 Lyngby, Denmark. ; Lawrence Livermore National Laboratory, Livermore, CA 94550, USA. ; Columbia Astrophysics Laboratory, Columbia University, New York, NY 10027, USA. ; Dipartimento di Matematica e Fisica, Universita degli Studi Roma Tre, Via della Vasca Navale 84, I-00146 Roma, Italy. ; Department of Astronomy, University of Michigan, Ann Arbor, MI 48109, USA. ; Department of Physics and Astronomy, University of Leicester, University Road, Leicester LE1 7RH, UK. ; Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA. ; Physics Department, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA. Eureka Scientific Inc., 2452 Delmer Street Suite 100, Oakland, CA 94602, USA. ; Department of Physics, University of Durham, South Road, Durham DH1 3LE, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25700515" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2017-12-01
    Description: Author(s): A. J. Beaudoin, P. A. Shade, J. C. Schuren, T. J. Turner, C. Woodward, J. V. Bernier, S. F. Li, D. M. Dimiduk, P. Kenesei, and J.-S. Park The plastic deformation of crystalline materials is usually modeled as smoothly progressing in space and time, yet modern studies show intermittency in the deformation dynamics of single-crystals arising from avalanche behavior of dislocation ensembles under uniform applied loads. However, once the ... [Phys. Rev. B 96, 174116] Published Thu Nov 30, 2017
    Keywords: Structure, structural phase transitions, mechanical properties, defects
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 635 (1991), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 7
  • 8
    Publication Date: 1993-10-15
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 9
    Publication Date: 2015-07-02
    Description: Ongoing studies with XMM–Newton have shown that powerful accretion disc winds, as revealed through highly ionized Fe K-shell absorption at E  ≥ 6.7 keV, are present in a significant fraction of active galactic nuclei (AGNs) in the local Universe (Tombesi et al. 2010a ). In Gofford et al., we analysed a sample of 51 Suzaku -observed AGNs and independently detected Fe K absorption in ~40 per cent of the sample, and we measured the properties of the absorbing gas. In this work, we build upon these results to consider the properties of the associated wind. On average, the fast winds ( v w  〉 0.01 c ) are located 〈 r 〉 ~ 10 15–18  cm (typically ~10 2–4 r s ) from their black hole, their mass outflow rates are of the order of $\langle \skew{3}\dot{M}_{\rm w}\rangle \sim 0.01\hbox{--}1$  M  yr –1 or ${\sim }(0.01\hbox{--}1)\skew{3}\dot{M}_{\rm Edd}$ and kinetic power is constrained to 〈 L w 〉 ~ 10 43–45  erg s –1 , equivalent to ~(0.1–10 per cent) L Edd . We find a fundamental correlation between the source bolometric luminosity and the wind velocity, with $v_{\rm w} \propto L_{\rm bol}^{\alpha }$ and $\alpha =0.4^{+0.3}_{-0.2}$ (90 per cent confidence), which indicates that more luminous AGN tend to harbour faster Fe K winds. The mass outflow rate $\skew{3}\dot{M}_{\rm w}$ , kinetic power L w and momentum flux $\dot{p}_{\rm w}$ of the winds are also consequently correlated with L bol , such that more massive and more energetic winds are present in more luminous AGN. We investigate these properties in the framework of a continuum-driven wind, showing that the observed relationships are broadly consistent with a wind being accelerated by continuum-scattering. We find that, globally, a significant fraction (~85 per cent) of the sample can plausibly exceed the L w / L bol  ~ 0.5 per cent threshold thought necessary for feedback, while 45 per cent may also exceed the less conservative ~5 per cent of L bol threshold as well. This suggests that the winds may be energetically significant for AGN–host-galaxy feedback processes.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 10
    Publication Date: 2015-10-02
    Description: Mkn 3 is a Seyfert 2 galaxy that is widely regarded as an exemplary Compton-thick Active Galactic Nucleus (AGN). We study the Suzaku X-ray spectrum using models of the X-ray reprocessor that self-consistently account for the Fe Kα fluorescent emission line and the associated Compton-scattered, or reflection, continuum. We find a solution in which the average global column density, $0.234^{+0.012}_{-0.010} \times 10^{24} \ \rm cm^{-2}$ , is very different to the line-of-sight column density, $0.902^{+0.012}_{-0.013} \times 10^{24} \ \rm cm^{-2}$ . The global column density is ~5 times smaller than that required for the matter distribution to be Compton thick. Our model accounts for the profiles of the Fe Kα and Fe Kβ lines, and the Fe K edge remarkably well, with a solar abundance of Fe. The matter distribution could consist of a clumpy medium with a line-of-sight column density higher than the global average. A uniform, spherically symmetric distribution alone cannot simultaneously produce the correct fluorescent line spectrum and reflection continuum. Previous works on Mkn 3, and other AGN, that assumed a reflection continuum from matter with an infinite column density could therefore lead to erroneous or ‘puzzling’ conclusions if the matter out of the line of sight is really Compton thin. Whereas studies of samples of AGN have generally only probed the line-of-sight column density, with simplistic, one-dimensional models, it is important now to establish the global column densities in AGN. It is the global properties that affect the energy budget in terms of reprocessing of X-rays into infrared emission, and that constrain population synthesis models of the cosmic X-ray background.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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