Publication Date:
1984-05-25
Description:
In vitro pharmacological studies demonstrated that exogenously applied vasoactive intestinal polypeptide (VIP) relaxes the smooth muscle cells of cat cerebral arteries, whereas substance P constricts them. Ultrastructural-immunocytochemical techniques show that a VIP-like substance is present in the large granular vesicles of nonsympathetic nerve axons and terminals in the cerebral arterial walls. These results provide strong evidence in favor of the hypothesis that a VIP-like substance is the transmitter for vasodilation in cerebral blood vessels.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, T J -- Saito, A -- Berezin, I -- BRSG S07RR0543/RR/NCRR NIH HHS/ -- HL 27763/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 May 25;224(4651):898-901.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719122" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cats
;
Cerebral Arteries/drug effects
;
*Cerebrovascular Circulation
;
In Vitro Techniques
;
Vasoactive Intestinal Peptide/pharmacology/*physiology
;
*Vasodilation
;
Vasomotor System/drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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