ISSN:
0935-6304
Keywords:
Capillary GC
;
Drug screening
;
Retention index
;
Reporting
;
Mean list length
;
Blood analysis
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A dual-column gas chromatographic retention index method was evaluated for the toxicological screening for basic drugs in autopsy blood samples. The dual-column approach with DB-5 and DB-1701 capillary columns doubles the Identification Power of the corresponding single column methods. The long-term intralaboratory variation of the dialkylfluoroaniline series based retention indices of drugs in blood ranged from 0.03% to 0.2% which was generally better than that obtained using the relative retention time. Novel software is described for the processing and reporting of the dual-column chromatographic data in analytically useful form. Besides retention data, the response factors served as an additional identification factor.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jhrc.1240190603
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