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  • 1
    Keywords: Cardiovascular system. ; Physiology. ; Biomedical engineering. ; Heart Surgery. ; Cardiology. ; Cardiovascular Physiology. ; Biomedical Engineering and Bioengineering. ; Cardiac Surgery. ; Cardiology.
    Description / Table of Contents: ANATOMY, PHYSIOLOGY, CONGENITAL DEFECTS, and DISEASE. - The anatomy and function of the atrioventricular valves -- The anatomy and function of the semilunar valves -- Congenital heart defects that include cardiac valve abnormalities -- Acquired valve disease and processes -- Complex repair of CHD requiring conduits OR valve replacement outside of the ROSS procedure -- VALVE REPAIR AND REPLACEMENT -- Heart valve disease -- History of heart valve repair -- The Ross Procedure -- The Use of Echocardiographic imaging of Valves -- Advanced 3D imaging (CT and MRI) and transcatheter valve repair/ implantation -- Transcatheter mitral repair and replacement -- Percutaneous pulmonary valve implantation: the first transcatheter valve -- Transcatheter aortic valve implantation -- Post TAVR PCI -- Complex Procedures in TAV, SAV, HARPOON, BASILICA w/ case studies -- Tissue engineered heart valves -- New trends for valve replacement like the Ozaki procedure -- Post-operative management of valves: On-X valve in post anticoagulation management -- TESTING, REGULATORY and TRAINING ISSUES -- In vitro testing of heart valve substitutes -- Numerical methods for design and evaluation of prosthetic heart valves -- Animal models for cardiac valve research -- The use of isolated heart models and anatomic specimens as means to enhance the design and testing of cardiac valve therapies -- Successful development and regulatory approval of replacement cardiac valves -- Clinical trial requirements for cardiac valves -- Virtual Prototyping and 3D Printing For Simulation -- Computational Modeling, Validation, Verification and Uncertainty: Device simulation in Valvular Anatomies -- Procedural Training and Education: Mixed Realities.
    Abstract: This state-of-the-art handbook is dedicated to cardiac valve anatomy, models for testing and research methods, clinical trials; and clinical needs and applications. In this new edition, chapters are updated with the latest research in addition to new chapters on complex repair of CHD requiring conduits, new trends for valve replacement like the Ozaki procedure, as well as complex procedures in TAV, SAV, HARPOON, and BASILICA, with case studies for each type of procedure. This volume serves as a helpful reference for patients, educators, students, device designers and developers, clinical study specialists, clinicians, and other associated healthcare providers.
    Type of Medium: Online Resource
    Pages: XVII, 615 p. 252 illus., 206 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031255410
    DDC: 573.1
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Molecular and cellular biochemistry 166 (1997), S. 85-94 
    ISSN: 1573-4919
    Keywords: nonesterified fatty acids ; myocardial metabolism ; myocardial ischemia ; reperfusion injury
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Long chain free fatty acids (FFA) are the preferred metabolic substrates of myocardium under aerobic conditions. However, under ischemic conditions long chain FFA have been shown to be harmful both clinically and experimentally. Serum levels of free fatty acids frequently are elevated in patients with myocardial ischemia. The proposed mechanisms of the detrimental effects of free fatty acids include: (1) accumulation of toxic intermediates of fatty acid metabolism, such as long chain acyl-CoA thioesters and long chain acylcarnitines, (2) inhibition of glucose utilization, particularly glycolysis, during ischemia and/or reperfusion, and (3) uncoupling of oxidative metabolism from electron transfer. The relative importance of these mechanisms remains controversial. The primary site of FFA-induced injury appears to be the sarcolemmal and intracellular membranes and their associated enzymes. Inhibitors of free fatty acid metabolism have been shown experimentally to decrease the size of myocardial infarction and lessen postischemic cardiac dysfunction in animal models of regional and global ischemia. The mechanism by which FFA inhibitors improve cardiac function in the postischemic heart is controversial. Whether the effects are dependent on decreased levels of long chain intermediates and/or enhancement of glucose utilization is under investigation. Manipulation of myocardial fatty acid metabolism may prove beneficial in the treatment of myocardial ischemia, particularly during situations of controlled ischemia and reperfusion, such as percutaneous transluminal coronary angioplasty and coronary artery bypass grafting. (Mol Cell Biochem 166: 85-94, 1997)
    Type of Medium: Electronic Resource
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