ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Substituted 4-oxoquinoline-3- (1a) and 4-oxo-1,8-naphthyridine-3- (1b) carboxylic acids are clinically useful antibacterial agents exerting their activity by inhibiting the subunit A of DNA gyrase. Recently, pyrimido-[1,6-a]benzimidazoles 2 were found to be a new class of inhibitors of this enzyme. As, in 1, replacement of C(8) by the N-atom was shown beneficial for the biological properties, a synthesis of the corresponding aza analogues of 2 has been carried out. The synthesis, DNA gyrase inhibitory activity, and in vitro antibacterial activity of the target compounds 16-19 are reported.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19940770419
Permalink