Publication Date:
2014-10-05
Description:
Article Dendritic cells (DCs) initiate distinct arms of immunity in response to different classes of pathogens. Here Gringhuis et al . show that DCs produce IL-27 upon sensing fucose-containing pathogen ligands via DC-SIGN, promoting follicular T helper cell differentiation and antibody production. Nature Communications doi: 10.1038/ncomms6074 Authors: Sonja I. Gringhuis, Tanja M. Kaptein, Brigitte A. Wevers, Michiel van der Vlist, Elsenoor J. Klaver, Irma van Die, Lianne E. M. Vriend, Marein A. W. P. de Jong, Teunis B. H. Geijtenbeek
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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