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  • 1
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    The non-coding skin: Exploring the roles of long non-coding RNAs in epidermal homeostasis and disease (2013)
    Wiley
    In: BioEssays
    Details
    Publication Date: 2013-09-26
    Description: Long non-coding RNAs (lncRNAs) have recently gained increasing attention because of their crucial roles in gene regulatory processes. Functional studies using mammalian skin as a model system have revealed their role in controlling normal tissue homeostasis as well as the transition to a diseased state. Here, we describe how lncRNAs regulate differentiation to preserve an undifferentiated epidermal progenitor compartment, and to maintain a functional skin permeability barrier. Furthermore, we will reflect on recent work analyzing the impact of lncRNAs on the progression from normal epithelium to the development of skin disorders and cancer. Long non-coding RNAs (lncRNAs) have recently been shown to control a wide variety of gene regulatory processes. In mammalian skin, lncRNAs appear to regulate the intricate balance between progenitor cells undergoing continual regeneration in the basal layer and highly differentiated cells forming the epidermal permeability barrier.
    Print ISSN: 0265-9247
    Electronic ISSN: 1521-1878
    Topics: Biology , Medicine
    Published by Wiley
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  • 2
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    The long non‐coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis (2019)
    Springer Nature
    Details
    Publication Date: 2019
    Description: lncRNA LINC00941 inhibits premature differentiation in weakly differentiated strata of the human epidermis through repression of previously uncharacterized SPRR5, shown here to promote keratinocyte differentiation. Abstract Several long non‐coding RNAs (lncRNAs) act as regulators of cellular homeostasis; however, few of these molecules were functionally characterized in a mature human tissue environment. Here, we report that the lncRNA LINC00941 is a crucial regulator of human epidermal homeostasis. LINC00941 is enriched in progenitor keratinocytes and acts as a repressor of keratinocyte differentiation. Furthermore, LINC00941 represses SPRR5, a previously uncharacterized molecule, which functions as an essential positive regulator of keratinocyte differentiation. Interestingly, 54.8% of genes repressed in SPRR5‐deficient epidermal tissue are induced in LINC00941‐depleted organotypic epidermis, suggesting a common mode of action for both molecules.
    Print ISSN: 1469-221X
    Electronic ISSN: 1469-3178
    Topics: Biology , Medicine
    Published by Springer Nature on behalf of The European Molecular Biology Organization (EMBO).
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