ISSN:
1432-1955
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Serum levels of interferon-gamma (IFN-γ) were evaluated inCalomys callosus, and Swiss mice during the course of infection by four strains ofTrypanosoma cruzi. All strains stimulated the production of this interleukine; however, the timing of its onset and permanence When chronically infected animals with no detectable serum IFN-γ were challenged with the homologous strain, they produced quantities comparable with those obtained during the acute phase of infection. InC. callosus there was a correlation between H2O2 liberation by peritoneal macrophages and serum IFN-γ levels, whereas no such correlation was found in mice.C. callosus had a higher capacity to heal histopathological lesions, whereas lesions in mice were progressive. The results obtained suggest thatC. callosus develops welladapted immune mechanisms that may be important for its role as a reservoir ofT. cruzi.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00931793
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