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  • 1
    Electronic Resource
    Electronic Resource
    Toward a Unified Approach to Genetic Mapping of Eukaryotes Based on Sequence Tagged Microsatellite Sites (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 930-932 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The genomes of all eukaryotes appear to contain a special class of loci, termed microsatellites, which can serve, if sequenced and taken as the substrate for the polymerase chain reaction, as highly informative, locus-specific markers. By analogy to the “sequence tagged sites” recently ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1090-930
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  • 2
    Electronic Resource
    Electronic Resource
    Molecular Markers in the Genetic Improvement of Farm Animals (1987)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 5 (1987), S. 573-576 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Molecular genetics provides the ability to uncover numerous and versatile genetic markers at the DNA level. At present, the most useful among these are restriction fragment length polymorphisms (RFLPs). We discuss here the possible applications of these methodologies to the genetic improvement of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0687-573
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  • 3
    Electronic Resource
    Electronic Resource
    Variable number of tandem repeats in the growth hormone gene of Sparus aurata: association with growth and effect on gene transcription (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Journal of fish biology 65 (2004), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The GH gene of Sparus aurata(saGH) contains variable number of tandem repeats (VNTR). The hyper-variable minisatellites in the first and third introns segregate in a Mendelian manner and exhibit numerous alleles. Analysis by PCR and sequencing of the two introns in several wild Sparidae species revealed comparable minisatellites with some variations. ‘Zoo blot’ with the first intron unit as a probe showed this sequence to be characteristic of several families from the Perciformes order. Unexpectedly, a similar minisatellite was found in the first intron of the GH gene in flounder, which belongs to a different order. Transfection of constructs containing a reporter gene and first intron of different length to four cell lines resulted in an inhibitory effect of the longer intron relative to the short intron. A (CA)n microsatellite (saGHpCA) is found in the GH promoter. A similar repeat at the same location is present in GH promoters of several other fish species. High variability (11 alleles) of the saGHpCA was found in a hatchery population. Full-sib family genotyping showed a Mendelian inheritance of these alleles. A significant association was found between allele distribution and body mass in large and average size fishes from a hatchery population. The intron minisatellites may serve as markers for hybrid population and parental assignment. Its presence in families and orders of the higher teleosts may help solving classification uncertainties. Their conservation and inhibitory effect suggest a biological role. The saGHpCA is correlated with growth and may be a good candidate for predicting growth performance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0022-1112.2004.00559ab.x
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  • 4
    Electronic Resource
    Electronic Resource
    On the power of experimental designs for the detection of linkage between marker loci and quantitative loci in crosses between inbred lines (1976)
    Springer
    Theoretical and applied genetics 47 (1976), S. 35-39 
    Details
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The power of experiments aimed at detecting linkage between a quantitative locus and a marker locus, both segregating in the backross or F2 generation of a cross between two inbred lines, is examined. Given that the two lines are close to fixation for alternative alleles of both marker locus and quantitative locus, it is concluded that experiments involving a few thousand offspring should be able to detect close linkages involving quantitative loci (or groups of loci) having rather modest effects (i.e., that contribute, say, 1% of the total phenotypic variance in the F2).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00277402
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  • 5
    Electronic Resource
    Electronic Resource
    Marker-based mapping of quantitative trait loci using replicated progenies (1990)
    Springer
    Theoretical and applied genetics 80 (1990), S. 205-208 
    Details
    ISSN: 1432-2242
    Keywords: Quantitative trait locus (QTL) ; Genetic markers ; Mapping QTL ; Recombinant inbred lines ; Doubled haploids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary When heritability of the trait under investigation is low, replicated progenies can bring about a major reduction in the number of individuals that need to be scored for marker genotype in determining linkage between marker loci and quantitative trait loci (QTL). Savings are greatest when heritability of the trait is low, but are much reduced when heritability of the quantitative trait is moderate to high. Required numbers for recombinant inbred lines will be greater than those required for a simple F2 population when heritabilities are moderate to high and the proportion of recombination between marker locus and quantitative trait locus is substantial.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00224388
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  • 6
    Electronic Resource
    Electronic Resource
    (TG)"n uncovers a sex-specific hybridization pattern in cattle
    Amsterdam : Elsevier
    Genomics 7 (1990), S. 31-36 
    Details
    ISSN: 0888-7543
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0888-7543(90)90515-V
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  • 7
    Electronic Resource
    Electronic Resource
    A genetic linkage map of the bovine genome (1994)
    [s.l.] : Nature Publishing Group
    Nature genetics 6 (1994), S. 227-235 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] A cattle genetic linkage map was constructed which marks about 90% of the expected length of the cattle genome. Over 200 DNA polymorphisms were genotyped in cattle families which comprise 295 individuals in full sibling pedigrees. One hundred and seventy–one loci were found linked to one ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng0394-227
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  • 8
    Electronic Resource
    Electronic Resource
    Genetic polymorphism in varietal identification and genetic improvement (1983)
    Springer
    Theoretical and applied genetics 67 (1983), S. 25-33 
    Details
    ISSN: 1432-2242
    Keywords: Genetic polymorphisms ; Genetic markers ; Genetic improvement ; Varietal identification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary New sources of genetic polymorphisms promise significant additions to the number of useful genetic markers in agricultural plants and animals, and prompt this review of potential applications of polymorphic genetic markers in plant and animal breeding. Two major areas of application can be distinguished. The first is based on the utilization of genetic markers to determine genetic relationships. These applications include varietal identification, protection of breeder's rights, and parentage determination. The second area of application is based on the use of genetic markers to identify and map loci affecting quantitative traits, and to monitor these loci during introgression or selection programs. A variety of breeding applications based on these possibilities can be envisaged for Selfers, particularly for those species having a relatively small genome size. These applications include: (i) screening genetic resources for useful quantitative trait alleles, and introgression of chromosome segments containing these alleles from resource strain to commercial variety; (ii) development of improved pure lines out of a cross between two existing commercial varieties; and (iii) development of crosses showing increased hybrid vigor. Breeding applications in segregating populations are more limited, particularly in species with a relatively large genome size. Potential applications, however, include: (i) preliminary selection of young males in dairy cattle on the basis of evaluated chromosomes of their proven sire; (ii) genetic analysis of resource strains characterized by high values for a particular quantitative trait, and introgression of chromosome segments carrying alleles contributing to the high values from resource strain to recipient strain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00303917
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  • 9
    Electronic Resource
    Electronic Resource
    Detection of linkage between marker loci and loci affecting quantitative traits in crosses between segregating populations (1988)
    Springer
    Theoretical and applied genetics 76 (1988), S. 228-236 
    Details
    ISSN: 1432-2242
    Keywords: Restriction fragment length polymorphisms (RFLPs) ; Variable number tandem repeat regions (VNTRs) ; Quantitative trait loci (QTL) ; Marker-QTL linkage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary By making use of pedigree information and information on marker-genotypes of the parent and F-1 individuals crossed to form an F-2 population, it is possible to carry out a linkage analysis between marker loci and loci affecting quantitative traits in a cross between segregating parent populations that are at fixation for alternative alleles at the QTL, but share the same alleles at the marker loci. For two-allele systems, depending on marker allele frequencies in the parent populations, 2–4 times as many F-2 offspring will have to be raised and scored for markers and quantitative traits in order to provide power equivalent to that obtained in a cross between fully inbred lines. Major savings in number of F-2 offspring raised can be achieved by scoring each parent pair for a large number of markers in each chromosomal region and scoring F-1 and F-2 offspring only for those markers for which the parents were homozygous for alternative alleles. For multiple allele systems, particularly when dealing with hypervariable loci, only 10%–20% additional F-2 offspring will have to be raised and scored to provide power equivalent to that obtained in a cross between inbred lines. When a resource population contains novel favorable alleles at quantitative trait loci that are not present (or rare) in a commercial population, analyses of this sort will enable the loci of interest to be identified, mapped and manipulated effectively in breeding programs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257850
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  • 10
    Electronic Resource
    Electronic Resource
    Selective genotyping for determination of linkage between a marker locus and a quantitative trait locus (1992)
    Springer
    Theoretical and applied genetics 85 (1992), S. 353-359 
    Details
    ISSN: 1432-2242
    Keywords: QTL ; Selective genotyping ; Genetic marker ; Linkage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary “Selective genotyping” is the term used when the determination of linkage between marker loci and quantitative trait loci (QTL) affecting some particular trait is carried out by genotyping only individuals from the high and low phenotypic tails of the entire sample population. Selective genotyping can markedly decrease the number of individuals genotyped for a given power at the expense of an increase in the number of individuals phenotyped. The optimum proportion of individuals genotyped from the point of view of minimizing costs for a given experimental power depends strongly on the cost of completely genotyping an individual for all of the markers included in the experiment (including the costs of obtaining a DNA sample) relative to the cost of rearing and trait evaluation of an individual. However, in single trait studies, it will almost never be useful to genotype more than the upper and lower 25% of a population. It is shown that the observed difference in quantitative trait values associated with alternative marker genotypes in the selected population can be much greater than the actual gene effect at the quantitative trait locus when the entire population is considered. An expression and a figure is provided for converting observed differences under selective genotyping to actual gene effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222881
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