Publication Date:
2020-12-05
Description:
Human metabolism is influenced by genetic and environmental factors. Previous studies have identified over 23 loci associated with more than 26 urine metabolites levels in adults, known as urinary metabolite quantitative trait loci or metabQTLs. The aim of the present study is the identification for the first time of urinary metabQTLs in children and their interaction with dietary patterns. Association between genome-wide genotyping data and 44 urine metabolite levels measured by 1H NMR was tested in 996 children from the Human Early Life Exposome (HELIX) project. Twelve statistically significant urine metabQTLs were identified, involving 11 unique loci and 10 different metabolites. Comparison with previous findings in adults revealed that six metabQTLs were already known, one had been described in serum and three involved the same locus as other reported metabQTLs but different urinary metabolites. The remaining two metabQTLs represent novel urine metabolite-locus associations, reported for the first time in this study (SNP rs12575496 for taurine, and the missense SNP rs2274870 for 3-hydroxyisobutyrate). Moreover, it was found that urinary taurine levels were affected by the combined action of genetic variation and dietary patterns of meat intake, as well as by the interaction of this SNP with beverage intake dietary patterns. Overall, we identified 12 urinary metabQTLs in children, including two novel associations. While a substantial part of the identified loci affected urinary metabolite levels both in children and in adults, the metabQTL for taurine seemed to be specific to children and interacted with dietary patterns.
Print ISSN:
0964-6906
Electronic ISSN:
1460-2083
Topics:
Biology
,
Medicine
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