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  • 1
    Electronic Resource
    Electronic Resource
    Endothelial cell compatibility testing of various prosthetic surfaces (1994)
    Springer
    Journal of materials science 5 (1994), S. 808-812 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Numerous methods are proposed to reduce the surface thrombogenicity of vascular prostheses, among them endothelialization of the lumen which has had clinical application since 1985. One of the problems is to collect enough cells to rapidly obtain a complete monolayer at the time of implantation. Thus, material improvements are necessary to enhance cell adhesion and spreading. A collaboration with the Bakoulev Institute (Moscow) gave us the opportunity to study the cytocompatibility of carbon coated materials (PAN and Vitlan®), polyester coated with albumin and/or synthetic polysaccharide. Studies were carried out with cultured human umbilical vein endothelial cells (HUVEC). Two steps are distinguished: indirect tests (medium added with materials extracts), then direct tests (cells directly seeded onto materials). Neither PAN, Vitlan® nor polyesters extracts have provoked a toxic effect on HUVEC. Concerning attachment on materials, a maximum of 60% of seeded cells is reached. Cells could proliferate and confluency is obtained between days 5 and 10 for the best materials. SEM corroborated these results. On polysaccharide-coated polyester (M. 11), HUVEC produced significant levels of vWF after thrombin stimulation (ELISA assay): vWF was functional (ristocetin cofactor activity). In conclusion, PAN and M. 11 gave encouraging results and further studies remain to be investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00213139
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  • 2
    Electronic Resource
    Electronic Resource
    An in vivo comparative study of the e-polytetrafluoroethylene vascular prostheses: Vitaflon and Gore-Tex (1999)
    Springer
    Journal of materials science 10 (1999), S. 783-786 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract A comparative study was performed in order to validate new Russian e-PTFE vascular prostheses Vitaflon (St. Petersburg, Russia). The Gore-Tex prostheses were chosen as a referential model. The prostheses were implanted in the venous and arterial positions in 13 dog experiments. After the implantation time was over a comprehensive histological and histochemical examination of excized specimens was performed. It was demonstrated that there is no difference in healing and functional properties between the two studied prostheses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008903117422
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  • 3
    Electronic Resource
    Electronic Resource
    Investigation of the thermostability of poly[bis(trifluoroethoxy)phosphazene] (1985)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 36 (1985), S. 627-631 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: An Poly[bis(trifluorethoxy)phosphazen] mit der Molmasse M̄Sη = 16·106 und sehr geringem Gehalt an chemisch andersartigen Kettengliedern (Gehalt an Gliedern mit unsubstituierten P—Cl-Gruppen nur 5,8·10-4 Molanteile) wurden medizinisch-biologische Untersuchungen durchgeführt. An Hunden als Versuchstieren wurden ex vivo über 100 Proben von Poly[bis(trifluorethoxy)phosphazen] in Form von Filmen und nahtlosen Röhrchen nach dem Thrombozytentest sowie der Dynamik der Thrombenbildung an der Wandung geprüft. Das untersuchte Polyfluoralkoxyphosphazen weist im Vergleich zu Polyethylen und Polytetrafluorethylen (für medizinische Zwecke) eine höhere Thrombenresistenz auf.
    Notes: Biomedical investigations of poly[bis(trifluoroethoxy)phosphazene] with M̄Sη, = 16 · 106 and a very regular composition of the chain have been carried out. The polymer contains only 5.8·10-4 mole fractions of anomalous units with unsubstituted P—Cl groups. More than 100 samples of poly[bis(trifluoroethoxy)phosphazene] as films and sutureless tubes were investigated in ex vivo experiments with dogs in respect to thrombocytic tests and the dynamics of parietal thrombogenesis. It is shown that the polyfluoroalkoxyphosphazene possesses higher thromboresistance than polyethylene and polytetrafluoroethylene.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1985.010361111
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