ISSN:
1573-6822
Keywords:
Ames assay
;
antiamoebic drug
;
antimalarial drug
;
antischistosomal drug
;
mutagen screening
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Seven antischistosomal drugs, two antimalarial drugs, and one antiamoebic drug were tested in all five Ames strains for induction of mutation, as well as for induction of cytotoxicity, inhibition of cellular progression, and the induction of sister chromatid exchanges in two cultured mammalian cell lines. We found that two agents shown to be negative in the Ames test were positive for sister chromatid exchange induction. Based on qualitative and quantitative evaluation, we find that all but three of the pharmaceuticals should be considered to be potential human carcinogens.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00121853
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