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  • 1
    Electronic Resource
    Electronic Resource
    THE KINETICS OF IgG AND IgM ANTIBODY-FORMING CELLS IN ACI AND F 344 RATS IMMUNIZED WITH POLY (Glu52Lys33Tyr15) (1977)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 4 (1977), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The cellular kinetics of antibody production in high and low responder rats immunized with poly(Glu52Lys33Tyr15) or with poly(Glu52Lys33Tyr15)/MeBSA were characterized: serum antibody and IgG and IgM antibody-forming cells in the spleen and in selected lymph nodes were assayed in male and female rats following immunization by several routes. Aggregation of the antigen with MeBSA enabled the poorly responding F344 rats to produce antibody, which was almost exclusively IgG. High responder ACI rats, under the same conditions, produced antibody of both IgG and IgM classes. These data suggest that in low responders one defect, possibly at the T-cell level, can be overcome by aggregation but that a second defect, involving the regulation of IgM production, still exists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1977.tb00622.x
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  • 2
    Electronic Resource
    Electronic Resource
    THE AVIDITY OF IgM ANTIBODY IN HIGH AND LOW RESPONDER RATS (1977)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 4 (1977), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: This study examined IgM antibody produced by highly responding ACI and poorly responding F344 rats following immunization with poly(Glu52Lys33Tyr15) or poly(Glu32Lys33Tyr15) aggregated with methylated bovine serum albumin (MeBSA). The ACI rats produced both IgM and IgG plaque-forming cells (PFC) following immunization with either form of antigen. The F344 rats did not respond to unaggregated poly(Glu52Lys33Tyr15), but they produced significant amounts of IgG PFC and extremely small amounts of IgM PFC after immunization with poly(Glu52Lys33Tyr15)/MeBSA. Both high and low responder rats had similar kinetic profiles of IgM antibody production, and this antibody had nearly identical avidity in both strains with no evidence for any maturation in avidity. thus, one of the genetic defects in the antibody response to poly(Glu52Lys33Tyr15) is an inability of the F344 strain to produce large amounts of IgM in response to this antigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1977.tb00623.x
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  • 3
    Electronic Resource
    Electronic Resource
    GENETIC STUDIES IN INBRED RATS. VI. LINKAGE RELATIONSHIPS OF MIXED LYMPHOCYTE REACTIVITY, SEROLOGICALLY DEFINED ANTIGENS (Ag-B, Ag-C) AND THE IMMUNE RESPONSE TO POLY(Glu52Lys33Tyr15) (1976)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 3 (1976), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The Ag-B allotype, mixed lymphocyte reactivity (MLR) and the immune response to poly(Glu52Lys33Tyr15) were assayed in male rats from the F2 hybrid and two back-cross generations of the F344 and DA strains in order to investigate the structure of the rat major histocompatibility complex. No disparity between Ag-B type and mixed lymphocyte reactivity was found in 263 animals. The immune response to poly(Glu52Lys33Tyr15) was closely linked to the Ag-B locus, and both antibody production and the delayed hypersensitivity response were under polygenic control. These results suggest that the genetic loci which determine these responses in the rat are closely linked and that recombinational events between the Ag-B and MLR loci are infrequent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1976.tb00556.x
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