Publication Date:
2019
Description:
Abstract
Conflicting data of the potential association between proton pump inhibitors (PPIs) and risk of dementia has been reported. This study aimed to examine the subsequent risk of incident dementia in older adults by categorizing subjects into different trajectories of longitudinal PPIs use. A group‐based trajectory modeling was used to identify distinct groups with regard to longitudinal PPIs use over 3 years and further examine the association between the trajectories of PPIs use and dementia in 5‐year follow‐up. Among 10,533 older adults who initiated PPIs, three distinct trajectories of longitudinal PPIs use were identified, i.e. short‐term (n=7406, 70.3%), intermittent (n=1528, 14.5%) and long‐term users (n=1599, 15.2%). Long‐term (HR=0.99 [95% CI 0.93‐1.17]) and intermittent PPI users (HR=0.91 [95% CI 0.76‐1.09]) were not associated with an increased risk of incident dementia compared to short‐term users. Regardless of pattern of use, PPIs did not appear to significantly increase the risk of dementia over a mean follow‐up period of 4 years.
This article is protected by copyright. All rights reserved.
Print ISSN:
0009-9236
Electronic ISSN:
1532-6535
Topics:
Chemistry and Pharmacology
,
Medicine
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