ISSN:
1573-9171
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary 1. Reductive amination of ketones in presence of platinized silica gel gives only primary amines. 2. The optimum reaction temperature lies in the range 170–240. 3. Aliphatic ketones having like radicals give higher yields of amines than ketones having unlike radicals. 4. Equal increases in the numbers of carbon atoms of the two identical radicals of a ketone do not lead to reduction in yield of amine. 5. Increase in the number of carbon atoms in only one of the radicals of the ketone leads to a reduction in the yield of amine. This reduction in yield is the greater, the greater the difference in the numbers of carbon atoms in the two radicals of the ketone. 6. In the the reductive amination reaction, cyclopentanone gives insignificant yields of amine, owing to the occurrence under these conditions of condensation and resinification reactions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01188237
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