ISSN:
1432-1041
Keywords:
Naproxen
;
suppository
;
bioavailability
;
tissue response
;
anti-inflammatory
;
analgetic
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The absorption of naproxen from Witepsol and Carbowax suppository bases was found to compare closely to that from an equivalent oral dose. Although the drug was readily absorbed from both rectal formulations, naproxen in Witepsol base produced a more rapid rise of plasma levels. — No significant local tissue irritation occurred following a course of six suppositories as determined by anoscopy and rectal biopsy. — No objective or subjective side effects were noted.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00561797
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