ISSN:
1573-8221
Keywords:
thyroxine
;
phospholipase mechanisms
;
swelling
;
inhibition
;
mitochondria
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The effect of thyroxine on various types of swelling of the mitochondria (calcium-, detergent-, valinomycin-, and peroxide-induced) was studied. Under conditions favoring swelling of the mitochondria through phospholipase activation (a low concentration of Mg2+ ions, the presence of Ca2+ ions in the incubation medium) thyroxine causes swelling of the organelles to develop faster. When the phospholipase mechanism of swelling of the mitochondria is inhibited (high concentrations of Mg2+ ions), thyroxine considerably inhibits the development of swelling of the mitochondria induced by lipid peroxidation, by virtue of its antioxidant action.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00798880
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