ISSN:
1432-1041
Keywords:
Healthy subjects
;
induced bronchoconstriction
;
dose response “slope”
;
bronchodilator drugs
;
salbutamol
;
methacholine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary To study whether it would be possible to assess bronchodilating drugs in healthy subjects with methacholine — induced bronchoconstriction, salbutamol 100, 200 and 300 μg was inhaled in random order by 12 healthy volunteers in a double-blind, placebo-controlled study. Dose response “slope” (DRS = maximum percentage fall in pulmonary function / maximal noncumulative methacholine dose (μmol)) was used as an index of bronchial reactivity, and was calculated for forced expiratory flow volume in 1 s (DRSFEV1) and area under the flow-volume curve (DRSAEFV). Bronchial reactivity and its reproducibility were first tested by a standard methacholine provocation method. An abbreviated, single-dose method was used to measure the effect of salbutamol. The reproducibility of methacholine provocation was good, and the single-dose and standard methods gave comparable results. The DRS-values of all the doses of salbutamol differed significantly from placebo and from each other. AEFV did not show any advantage over the FEV1 in this context. A significant negative association between the dose of salbutamol (μg/kg) and airway reactivity was observed. In conclusion, use of the DRS showed it possible to evaluate the protective efficacy of β2-adrenergic agonists against induced bronchoconstriction in healthy subjects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00316095
Permalink