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  • 1
    Electronic Resource
    Electronic Resource
    The RAG Proteins and V(D)J Recombination: Complexes, Ends, and Transposition (2000)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 18 (2000), S. 495-527 
    Details
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract V(D)J recombination proceeds through a series of protein:DNA complexes mediated in part by the RAG1 and RAG2 proteins. These proteins are responsible for sequence-specific DNA recognition and DNA cleavage, and they appear to perform multiple postcleavage roles in the reaction as well. Here we review the interaction of the RAG proteins with DNA, the chemistry of the cleavage reaction, and the higher order complexes in which these events take place. We also discuss postcleavage functions of the RAG proteins, including recent evidence indicating that they initiate the process of coding end processing by nicking hairpin DNA termini. Finally, we discuss the evolutionary and functional implications of the finding that RAG1 and RAG2 constitute a transposase, and we consider RAG protein biochemistry in the context of several bacterial transposition systems. This suggests a model of the RAG protein active site in which two divalent metal ions serve alternating and opposite roles as activators of attacking hydroxyl groups and stabilizers of oxyanion leaving groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.immunol.18.1.495
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  • 2
    Electronic Resource
    Electronic Resource
    DNA repair Breaking the seal (2002)
    [s.l.] : Nature Publishing Group
    Nature 416 (2002), S. 691-694 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] One hallmark of our immune system is its ability to recognize and react efficiently to a nearly infinite variety of infectious microorganisms. Such remarkable versatility stems from a cut-and-paste process that rearranges the genome of immune cells as they develop. These cells — B and T ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/416691a
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  • 3
    Electronic Resource
    Electronic Resource
    Mutations in the gene for the common gamma chain (γc) in X-linked severe combined immunodeficiency (1998)
    Springer
    Human genetics 〈Berlin〉 103 (1998), S. 730-731 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract X-linked severe combined immunodeficiency (XSCID) consitutes a disorder of the immune system caused by mutations in the gene encoding the common gamma chain (γc), a subunit of the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors, which are necessary for lymphocyte development and function. In this study the IL2RG gene of 31 patients with severe combined immunodeficiency (SCID) was examined by nonradioactive single-strand conformation polymorphism and sequence analysis. Among the 11 patients with XSCID, ten different mutations were identified in the IL2RG gene, including eight novel mutations. Ninety percent of the mothers of the XSCID patients are carriers of the mutated allele. One patient showed low numbers of B-cells, a striking deviation from the classical B-cell-positive and T-cell-negative phenotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008710
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  • 4
    Electronic Resource
    Electronic Resource
    Determination of nalbuphine hydrochloride, methylparaben, and propylparaben in nalbuphine hydrochloride injection by high performance liquid chromatography (1998)
    Springer
    Chromatographia 47 (1998), S. 515-522 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; 4,5-Epoxymorphinan ; Nalbuphine hydrochloride injection ; Stability assays
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A stability-indicating liquid chromatographic method has been developed for the determination of nalbuphine hydrochloride, methylparaben, and propylparaben in nalbuphine hydrochloride injection. Reversed-phase chromatography was carried out using a mobile phase containing 0.05 % trifuoroacetic acid, acetonitrile, and tetrahydrofuran. Quantitation was achieved with UV detection at 280 nm. Validation data for linearity, accuracy, precision, specificity, and robustness are presented. The chromatographic system resolves nalbuphine from synthetic impurities and degradation products.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02467488
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  • 5
    Electronic Resource
    Electronic Resource
    On the convergence of sequential minimization algorithms (1973)
    Springer
    Journal of optimization theory and applications 12 (1973), S. 567-575 
    Details
    ISSN: 1573-2878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract This note discusses the conditions for convergence of algorithms for finding the minimum of a function of several variables which are based on solving a sequence of one-variable minimization problems. Theorems are given which contrast the weakest conditions for convergence of gradient-related algorithms with those for more general algorithms, including those which minimize in turn along a sequence of uniformly linearly independent search directions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00934779
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  • 6
    Electronic Resource
    Electronic Resource
    On the convergence of sequential minimization algorithms (1974)
    Springer
    Journal of optimization theory and applications 14 (1974), S. 439-442 
    Details
    ISSN: 1573-2878
    Keywords: Unconstrained minimization ; convergence theorems ; descent methods ; gradient methods ; global convergence proofs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract This note gives a proof of convergence of a class of gradient-related minimization algorithms under slightly weaker conditions than were used in a recent paper (see Ref. 1) on the same subject.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00933310
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  • 7
    Electronic Resource
    Electronic Resource
    A study of chain-addition polymerizations with temperature variations. IV. Copolymerizations - Experiments with styrene-acrylonitrile (1979)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 19 (1979), S. 190-197 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Free-radical copolymerizations were studied under nonisothermal conditions with emphasis on their thermal runaway and ignition behavior. Computational models are presented in generalized form and compared with experiments on the system styrene-acrylonitrile. A new, useful method is proposed for the evaluation of runaway parameters from scant kinetic data.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760190305
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  • 8
    Electronic Resource
    Electronic Resource
    A study of chain addition polymerizations with temperature variations: III. Thermal runaway and instability in styrene polymerization - an experimental study (1976)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 16 (1976), S. 117-123 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Thermal runaway arid parametric sensitivity were experimentally demonstrated in styrene polymerizations. Ignition boundaries were established for several initiator concentrations and a dimensionless boundary plotted. Runaway sensitivity was shown to disappear under specific conditions.
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760160208
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  • 9
    Electronic Resource
    Electronic Resource
    Thermal ignition phenomena in chain-addition copolymerizations (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 23 (1979), S. 661-686 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Thermal ignition theory has been extended to include free-radical copolymerizations resulting in dimensionless criteria for runaway and ignition. These criteria were verified by computer simulation and preliminary experimentation. Approximate, but greatly simplified, material and energy balances describing nonisothermal copolymerizations were developed which are similar in form to those describing nonisothermal homopolymerizations. Regions of close agreement, as well as disagreement, between conversion and temperature histories from these approximations and those from the exact balances are described.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1979.070230303
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  • 10
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    III.7 Planets orbiting stars more massive than the Sun (2022)
    EDP SCIENCES
    Details
    Publication Date: 2024-04-04
    Description: This book is dedicated to all the people interested in the CoRoT mission and the beautiful data that were delivered during its six year duration. Either amateurs, professional, young or senior researchers, they will find treasures not only at the time of this publication but also in the future twenty or thirty years. It presents the data in their final version, explains how they have been obtained, how to handle them, describes the tools necessary to understand them, and where to find them. It also highlights the most striking first results obtained up to now. CoRoT has opened several unexpected directions of research and certainly new ones still to be discovered.
    Keywords: photometry ; space mission ; bic Book Industry Communication::P Mathematics & science::PH Physics ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: English
    Format: image/jpeg
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