Publication Date:
2017-01-01
Description:
Conditional power of survival endpoints at interim analyses can support decisions on continuing a trial or stopping it for futility. When a cure fraction becomes apparent, conditional power cannot be calculated accurately using simple survival models, e.g. the exponential model. Non-mixture models consider such cure fractions. In this paper, we derive conditional power functions for non-mixture models, namely the non-mixture exponential, the non-mixture Weibull, and the non-mixture Gamma models. Formulae were implemented in the
Print ISSN:
2194-573X
Electronic ISSN:
1557-4679
Topics:
Biology
,
Mathematics
,
Medicine
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