Publication Date:
2014-08-23
Description:
Article Two-pore channel 2 has been implicated in coupling changes in cellular energy status with endolysosomal function. Grimm et al. show that mice lacking this channel display defects in endolysosomal trafficking of LDL-cholesterol and are susceptible to hepatic cholesterol overload and fatty liver disease. Nature Communications doi: 10.1038/ncomms5699 Authors: Christian Grimm, Lesca M. Holdt, Cheng-Chang Chen, Sami Hassan, Christoph Müller, Simone Jörs, Hartmut Cuny, Sandra Kissing, Bernd Schröder, Elisabeth Butz, Bernd Northoff, Jan Castonguay, Christian A. Luber, Markus Moser, Saskia Spahn, Renate Lüllmann-Rauch, Christina Fendel, Norbert Klugbauer, Oliver Griesbeck, Albert Haas, Matthias Mann, Franz Bracher, Daniel Teupser, Paul Saftig, Martin Biel, Christian Wahl-Schott
Electronic ISSN:
2041-1723
Topics:
Biology
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Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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