ISSN:
1432-1432
Keywords:
Repetitive DNA
;
Retroposon
;
Pseudogene
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary We present approximately 7.0 kb of composite DNA sequence of a long interspersed middle repetitive element (LINE1) present in high copy number in the rat genome. The family of these repeats, which includes transcribing members, is the rat homologue of the mouse MIF-Bam-R and human Kpn I LINEs. Sequence alignments between speciments from these three species define the length of a putative unidentified open reading frame, and document extensive recombination events that, in conjunction with retroposition, have generated this large family of pseudogenes and pseudogene fragments. Comparative mapping of truncated elements indicates that a specific endonucleolytic activity might bei involved in illegitimate (nonhomologous) recombination events. Sequence divergence analyses provide insights into the origin and molecular evolution of these elements.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02101690
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