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  • 1
    Electronic Resource
    Electronic Resource
    Determination of the enantiomers of flecainide and two major metabolites in man by gas chromatography/mass spectrometry using negative ion chemical ionization and stable isotope labelled internal standards (1990)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 19 (1990), S. 256-266 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The class I antiarrhythmic drug flecainide (1) is used clinically as racemate. In order to study the stereochemical disposition and excretion of 1 an analytical method has been developed based on a deuterated analogue of 1 as internal standard and on measurement with gas chromatography/mass spectrometry (GC/MS) using negative ion chemical ionization (NICI). Several diasteromeric derivatives prepared were separated on an achiral capillary column. All derivatives exhibited negative ion properties forming characteristic fragments: [M — CH2CF3]- and [M — HF]-., respectively. The limit of detection was 1 pmol ml-1 plasma corresponding to 0.41 ng ml-1 of free base. A more convenient and in particular more precise approach was investigated by separating the pentafluoropropionyl (PFP) derivatives on a chiral phase capillary column monitoring the base peak [M — 20]-. in NICI mode. This method is not only the most sensitive assay of 1 presently available, but also allows for the determination of the enantiomers of flecainide in biological fluids. In addition, the assay could be applied to the dtermination of the enantiomers of one of the major metabolites of flecainide, the meta-O-dealkylated flecainide (MODF), in human urine. Additionally, a non-sterospecific assay was developed and applied to the quantification of the two major metabolites of flecainide, MODF and the meta-O-dealkylated flecainide lactam in human urine. Deuterated analogues were used as internal standards and measurement of the PFP derivatives with GC/MS using NICI was performed.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200190410
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    Paper (German National Licenses)
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  • 2
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    Poly (Butyl Acrylate)-Graft-Polystyrene Synthesis by Free-Radical Polymerization: Interplay between Structure, Morphology, Mechanical, and Optical Properties (2019)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2019-08-07
    Description: We report a new method of preparation of poly (butyl acrylate)-g-polystyrene/polystyrene blends by free-radical polymerization. Copolymerization of glycidyl (meth)acrylate with butyl acrylate is followed by a polymer analogous reaction of this copolymer with acrylic acid and subsequent copolymerization of the modified backbone with styrene. Investigation on the number of reactive groups per backbone chain and its molecular weight allows grafting efficiencies of about 35% to be reached, as well as low cross-linking. Blends of nanophase-separated copolymers having a backbone with Mn of around 50 kg/mol and 4 reactive groups per chain are transparent, with haze as low as 14%, tensile strength of around 22 MPa, and elongations at the break of around 3%. Correlation between morphology determined by transmission electron microscopy and properties of the blend is established.
    Electronic ISSN: 2073-4360
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Process Engineering, Biotechnology, Nutrition Technology
    Published by Molecular Diversity Preservation International
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