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  • 1
    Electronic Resource
    Electronic Resource
    Qualitatively different induction of germ cell mutations by heavy ions (1988)
    Springer
    Radiation and environmental biophysics 27 (1988), S. 133-141 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary The problem of the dependence of the biological efficiency of ionizing radiation on the Linear Energy Transfer (LET) is still unsolved. Unexpected reactions of heavy ion irradiated cellular systems such as an increasing Relative Biological Effectiveness (RBE) up to a LET of about 100 keV/µm and then a decrease below 1 oblige to dismiss some conventional interpretations. Several years ago we suggested that, especially by higher ionization density in addition to the DNA, repair systems and (or) membraneous systems could also be injured (dual target theory). Our experiments with heavy ions at the Lawrence Berkeley Laboratory with LET's between 102–970 keV/µm on different types of mutations show a strict distinction between events connected with fusion modalities (repair or misrepair) and those associated with nonfusion. With very high LET misrepair reactions such as translocations disappear, suggesting the direct damage of the repair systems and confirming our previous experiments with peak pions and ions of LET's between 1100–4800 keV/µm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01214603
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  • 2
    Electronic Resource
    Electronic Resource
    Piotron pion irradiation of cerebral capillaries in neonatal rats (1982)
    Springer
    Radiation and environmental biophysics 21 (1982), S. 75-80 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary The microvasculature of the neonatal rat brain and its radiation-induced petechial hemorrhages were used as an in vivo model for studying the effect of negative pions on healthy normal tissue. By means of dose response curves (range: 2–6 gray) the RBE of peak pions with respect to 220 kVp X-rays was calculated. Whereas earlier studies involved irradiations with single beam pions (πE3) of low dose rate (0.06–0.11 Gy per min) the present work was performed using pions of a multiport applicator (Piotron) of higher dose rate (1 Gy per min). The results obtained by Piotron pions agreed well with those obtained byπE3 pions resulting in a RBE of 1.1. The difference between pion and X-rays, however, was statistically not significant. 0-(beta-hydroxyethyl)-rutosides known for their protective effect on radiation damage induced by either X-rays or electrons were used for evaluating any radioprotective effect on pion-induced damage of the microvasculature. They were applied subcutaneously in doses of 450 mg/kg body weight 30 min prior to irradiation. It could be demonstrated that the rutosides decreased the pion-induced radiation response significantly by a factor of 1.3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01323639
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  • 3
    Electronic Resource
    Electronic Resource
    Combined application of misonidazole and piotron pions on mouse embryos (1983)
    Springer
    Radiation and environmental biophysics 21 (1983), S. 155-162 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary Mouse embryos on day 8 of gestation were irradiated with negative pions (12.5–100 rad) or 200 kV X-rays (12.5–150 rad). Misonidazole (MISO), a hypoxic cell radiosensitizer, was applied 30 min before exposure. On day 13 the fetuses were examined for lethality, growth retardation and malformation. No significant embryolethal effects were observed after irradiation alone in the dose range of 12.5–100 rad (X-rays or pions). However, MISO alone and in combination with radiation led to high rates of lethality. The frequency of growth retardation was significantly increased at 100 rad and in combined treatments at low radiation doses. MISO and irradiation with 50 rad and more induced complex damages consisting of multiple and severe malformations and growth retardation. The relative biological effectiveness (RBE) for teratogenic effects was 1.6. In conclusion, the combined application of MISO and radiation of different LET revealed a strong enhancing action compared to single treatments. The extent of enhancement depends on both radiation quality and dose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01323408
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