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  • 1
    Electronic Resource
    Electronic Resource
    Comparative studies on the postantifungal effect produced by the synergistic interaction of flucytosine and amphotericin B on Candida albicans (1992)
    Springer
    Mycopathologia 120 (1992), S. 133-138 
    Details
    ISSN: 1573-0832
    Keywords: Amphotericin B ; antimicrobial agents ; Candida albicans ; flucytosine ; in vitro susceptibility assay ; postantifungal effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A turbidometric method was used to measure Candida albicans yeast cell growth and to quantitate the postantifungal effect (PAFE) after exposure to various concentrations of flucytosine and amphotericin B, alone and in combination, for 2 hr at 30°C. The drug concentrations used in the PAFE assays were determined by initial MIC and FIC (fractional inhibitory concentration) evaluations. The PAFE was calculated by the difference in time (hr) required for growth of the control and test cultures to reach the 0.5 absorbance level following removal of the drug by dilution. A synergistic PAFE was evidenced with combinations of the two drugs at concentrations below their individual MICs. Combinations of flucytosine (0.012 to 0.049 μg ml−1) and amphotericin B (0.195 to 0.39 μg ml−1) produced PAFEs ranging from 6.3 to 21.8 hr. These PAFEs persisted from 0.3 to 14.7 hr longer than those achieved when each of the two agents was assayed separately.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00436389
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  • 2
    Electronic Resource
    Electronic Resource
    Detection of antibody responses and delayed dermal hypersensitivity with Blastomyces dermatitidis yeast and mycelial lysate antigens (1991)
    Springer
    Mycopathologia 114 (1991), S. 137-144 
    Details
    ISSN: 1573-0832
    Keywords: Blastomyces dermatitidis ; blastomycosis ; canine blastomycosis ; ELISA ; enzyme immunoassay ; fungal immunodiagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Yeast cell lysate and mycelial lysate antigens prepared from one strain (T-58) of Blastomyces dermatitidis were evaluated with respect to the detection of antibodies and delayed dermal hypersensitivity. Comparable ELISA sensitivity values were evidenced with the two antigens when assayed against serum specimens from dogs with blastomycosis, sera from non-infected dogs residing in endemic and nonendemic areas for blastomycosis and sera from rabbits that were hyperimmunized with B. dermatitidis antigens. Specificity determinations with anti -Histoplasma capsulatum rabbit sera indicated that both reagents exhibited only minimal cross-reactivity; the mycelial antigen was slightly more specific than the yeast phase reagent. Similar sensitivity and specificity results were experienced when the two antigens were used to detect delayed dermal hypersensitivity in guinea pigs previously sensitized with B. dermatitidis or H. capsulatum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00437202
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  • 3
    Electronic Resource
    Electronic Resource
    Circling syndrome and inner ear disease in mice infected intraperitoneally or intravenously with Coccidioides immitis spherule-endospore phase cultures (1983)
    Springer
    Mycopathologia 83 (1983), S. 75-86 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Infection was studied in mice with varying doses of spherule-endospore phase cultures of Coccidioides immitis, administered intraperitoneally, intravenously and intranasally. Stain 46 was compared with strain Silveira. The first of these is relatively avirulent in the mycelial phase, the second, rather virulent. Animals were observed for acute death and for circling. Gross and microscopic pathology was studied in mice sacrificed at appropriate intervals after infection. Numbers of fungi were assayed in spleen, lung, kidney, liver, blood, brain, and ear tissue. Strain 46 endospores administered intraperitoneally in doses from 9 × 106 to 2.5 × 107 produced a high incidence of ‘circling syndrome’ ataxia attributable to inner ear disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00436887
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