ISSN:
0887-6134
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The combination of gas chromatography and mass spectrometry (GC/MS) is effective for separation and identification of the hydroxylamine metabolites of alicyclic primary amines after acetylation. These products give mass spectra contianing diagnostic fragment ions which are of great value for identification of metabolites. The mass spectra of diacetyl alicyclic primary hydroxylamines gave prominent characteristic peaks at m/z (M - 42), (M - 42 - 42), (M - 101), 118 (AcNOAc) and 76 (AcNOH). GC/MS analysis of the incubation extracts has shown that the N-hydroxylamines are the major metabolites of alicyclic primary amines in rabbit liver microsomes.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bms.1200180913
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