Publication Date:
2015-12-03
Description:
Background: Stenotrophomonas maltophilia (S. maltophilia) bacteremia in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients is associated with significant morbidity and mortality rate. Although several predisposing risk factors for S. maltophilia bacteremia following allo-HSCT have been identified, there is no agreement or consistency among clinical factors on whether to predict treatment outcome or not. Methods: From January 2005 to December 2014, data on demographic and clinical characteristics, treatment and outcome were collected for all S. maltophilia bacteremia cases observed at an 800-bed tertiary care hospital with a 32-bed transplantation ward. They were analyzed with respect to incidence and 90-day mortality. The risk factors associated with 90-day mortality of allo-HSCT recipients with S. maltophilia bacteremia were also analyzed by Log-rank test according to age, sex, neutropenia, platelet, C-reactive protein (CRP), albumin, creatinine, engraftment, graft-versus-host disease, primary disease risk, severe sepsis or septic shock, complicated infection, and conditioning intensity. Significant variables in the univariate analysis were included in the multivariate Cox proportional-hazards regression model. Results: A total of 65 patients (47 patients in allo-HSCT recipients and 18 patients in non allo-HSCT recipients) with S. maltophilia bacteremia were identified, with the incidence of 1.17 cases per 100 admissions and 0.35 cases per 1000 patient-days. The incidence was significantly high in allo-HSCT recipients compared to non allo-HSCT recipients (6.53 vs 0.36 per 100 admission, p
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
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