ISSN:
1476-5535
Schlagwort(e):
Keywords: compactin; optimization; regression analysis; Penicillium
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
,
Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
Notizen:
A compactin producer Penicillium sp strain was isolated from soil in our screening program. The compactin-biosynthesising capacity of the strain was improved from 5 μg ml−1 to 250 μg ml−1 by mutation-selection method. We investigated the effect of the medium composition on compactin productivity. A central, orthogonal three-factor experimental design by Box and Wilson was used in the investigation. The results were analysed by non-linear regression analysis. The composition of the production medium was optimized according to the calculated mathematical model using the steepest ascent method. The compactin productivity was increased to 400 μg ml−1 by applying this method.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1038/sj.jim.2900508
Permalink