ISSN:
1550-7408
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
Notes:
SYNOPSIS. Inhibitory activity of a series of drugs has been tested against Trichomonas vaginalis pour-plated in agar. Drugs were applied in impregnated paper discs on the surface of the agar and activities determined by the presence of surrounding zones without growth. Control discs without drug showed no inhibition of the flagellate's growth.Some relationships of structure to activity were found in a group of substituted nitroimidazoles and nitrothiazoles. Diamidines, except for one with a triazene nucleus, produced little or no effect. Antibiotics varied from very high activity to none; a group of miscellaneous compounds, not quite so widely. Among the antibiotics, thiolutin merits further study as a possible biotin antagonist. Three closely related drugs, one of them known to inhibit cholesterol synthesis in mammals and Protozoa, restricted growth of T. vaginalis.Suggestions are made as to further uses of disc or strip tests with plated trichomonads for studies of nutrition, metabolism, and genetics.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1550-7408.1962.tb02613.x
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