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  • 1
    Monograph available for loan
    Monograph available for loan
    If the universe Is teeming with aliens.... Where is everybody? : Fifty solutions to the fermi paradox and the problem of extraterrestrial life (2002)
    Berlin [u.a.] : Springer
    Details Availability
    Call number: PIK N 322-02-0402
    Type of Medium: Monograph available for loan
    Pages: 290 p.
    ISBN: 0387955011
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 2
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    Episodic stress and fluid pressure cycling in subducting oceanic crust during slow slip (2019)
    Springer Nature
    Details
    Publication Date: 2019
    Print ISSN: 1752-0894
    Electronic ISSN: 1752-0908
    Topics: Geosciences
    Published by Springer Nature
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  • 3
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    Generation of iN cells from aging fibroblasts [Neuroscience] (2016)
    National Academy of Sciences
    Details
    Publication Date: 2016-07-28
    Description: We and others have shown that embryonic and neonatal fibroblasts can be directly converted into induced neuronal (iN) cells with mature functional properties. Reprogramming of fibroblasts from adult and aged mice, however, has not yet been explored in detail. The ability to generate fully functional iN cells from aged organisms...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 4
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    The rare earth element signal in Archaean microbial carbonate: information on ocean redox and biogenicity (2014)
    Geological Society of London
    Details
    Publication Date: 2014-11-07
    Description: Microbial carbonates contain valuable chemical, isotopic and molecular information regarding the Precambrian Earth. They record shallow-water information complementary to deep ocean proxies, such as banded iron formation and black shale. Six groups of well-preserved stromatolites illustrate how the rare earth elements (REE) are used for chemical investigation. The first task is to test whether the REE inventory of carbonate is compromised by clastic, volcanic, or diagenetic contaminants. Once the cleanliness has been verified, the shale-normalized REE pattern can be used to distinguish between marine and lacustrine settings. For marine carbonates, it is possible to distinguish between restricted basin and open marine settings and for thick platform limestones the relative water depth can be inferred from REE systematics. The studied shallow-water stromatolites range in age from 2.52 to 3.45 Ga. They contain no evidence from the behaviour of the redox-sensitive element cerium that free oxygen levels in the shallow sea approached concentrations beyond a trace gas by 2.52 Ga. Compared with abiotic early diagenetic marine carbonate cements, microbial carbonate is strongly enriched in REE. This may itself not yet serve as a biomarker, but it is regarded as a necessary prerequisite for a sample to qualify for biomarker studies.
    Print ISSN: 0016-7649
    Topics: Geosciences
    Published by Geological Society of London
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  • 5
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    A robust deuterium abundance; re-measurement of the z = 3.256 absorption system towards the quasar PKS 1937-101 (2015)
    Oxford University Press
    Details
    Publication Date: 2015-01-20
    Description: The primordial deuterium abundance is an important tracer of the fundamental physics taking place during big bang nucleosynthesis. It can be determined from absorption features along the line of sight to distant quasars. The quasar PKS 1937–1009 contains two absorptions systems that have been used to measure the primordial deuterium abundance, the lower redshift one being at z abs  = 3.256. New observations of this absorber are of a substantially higher signal-to-noise ratio and thus permit a significantly more robust estimate of the primordial deuterium abundance, leading to a D i /H i ratio of 2.45 ± 0.28 10 –5 . Whilst the precision of the new measurement presented here is below that obtained from the recent cosmological parameter measurements by the Planck Surveyor, our analysis illustrates how a statistical sample obtained using similarly high spectral signal-to-noise ratio can make deuterium a competitive and complementary cosmological parameter estimator and provide an explanation for the scatter seen between some existing deuterium measurements.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 6
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    Rapid Damage Mapping for the 2015 Mw 7.8 Gorkha Earthquake Using Synthetic Aperture Radar Data from COSMO-SkyMed and ALOS-2 Satellites (2015)
    Seismological Society of America (SSA)
    Details
    Publication Date: 2015-10-29
    Description: The 25 April 2015 M w  7.8 Gorkha earthquake caused more than 8000 fatalities and widespread building damage in central Nepal. The Italian Space Agency’s COSMO–SkyMed Synthetic Aperture Radar (SAR) satellite acquired data over Kathmandu area four days after the earthquake and the Japan Aerospace Exploration Agency’s Advanced Land Observing Satellite-2 SAR satellite for larger area nine days after the mainshock. We used these radar observations and rapidly produced damage proxy maps (DPMs) derived from temporal changes in Interferometric SAR coherence. Our DPMs were qualitatively validated through comparison with independent damage analyses by the National Geospatial-Intelligence Agency and the United Nations Institute for Training and Research’s United Nations Operational Satellite Applications Programme, and based on our own visual inspection of DigitalGlobe’s WorldView optical pre- versus postevent imagery. Our maps were quickly released to responding agencies and the public, and used for damage assessment, determining inspection/imaging priorities, and reconnaissance fieldwork.
    Print ISSN: 0895-0695
    Electronic ISSN: 1938-2057
    Topics: Geosciences
    Published by Seismological Society of America (SSA)
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  • 7
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    Influence of bias correction on simulated landcover changes (2012)
    Wiley
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    Publication Date: 2012-08-24
    Description: Vegetation responses to climate change will provide feedbacks that could amplify or moderate regional temperature and precipitation changes. However, systematic biases in the simulation of regional climate across general circulation models (GCMs) may lead to consistent misrepresentation of vegetation changes and associated ecological processes. This study uses Köppen classification driven by simulated climate with and without bias correction. Our results indicate that because climate biases lead to inaccuracies in land cover, corrected and uncorrected analyses result in distinct land cover changes in regions (the tropics and high-latitude Northern Hemisphere) that have strong climate feedbacks, even though the climate change is identical. While a more realistic biosphere may ameliorate some model biases, our results illustrate the potential for existing errors to influence feedbacks and suggest that, as models become more complex, nuanced understanding of bias propagation will be critical in assessing the uncertainty of projections and common downscaling techniques.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 8
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    Short-term diversification of biofilm populations [Microbiology] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-04-09
    Description: Generation of genetic diversity is a prerequisite for bacterial evolution and adaptation. Short-term diversification and selection within populations is, however, largely uncharacterised, as existing studies typically focus on fixed substitutions. Here, we use whole-genome deep-sequencing to capture the spectrum of mutations arising during biofilm development for two Pseudomonas aeruginosa strains....
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 9
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    A widespread family of polymorphic contact-dependent toxin delivery systems in bacteria (2010)
    Nature Publishing Group (NPG)
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    Publication Date: 2010-11-19
    Description: Bacteria have developed mechanisms to communicate and compete with one another in diverse environments. A new form of intercellular communication, contact-dependent growth inhibition (CDI), was discovered recently in Escherichia coli. CDI is mediated by the CdiB/CdiA two-partner secretion (TPS) system. CdiB facilitates secretion of the CdiA 'exoprotein' onto the cell surface. An additional small immunity protein (CdiI) protects CDI(+) cells from autoinhibition. The mechanisms by which CDI blocks cell growth and by which CdiI counteracts this growth arrest are unknown. Moreover, the existence of CDI activity in other bacteria has not been explored. Here we show that the CDI growth inhibitory activity resides within the carboxy-terminal region of CdiA (CdiA-CT), and that CdiI binds and inactivates cognate CdiA-CT, but not heterologous CdiA-CT. Bioinformatic and experimental analyses show that multiple bacterial species encode functional CDI systems with high sequence variability in the CdiA-CT and CdiI coding regions. CdiA-CT heterogeneity implies that a range of toxic activities are used during CDI. Indeed, CdiA-CTs from uropathogenic E. coli and the plant pathogen Dickeya dadantii have different nuclease activities, each providing a distinct mechanism of growth inhibition. Finally, we show that bacteria lacking the CdiA-CT and CdiI coding regions are unable to compete with isogenic wild-type CDI(+) cells both in laboratory media and on a eukaryotic host. Taken together, these results suggest that CDI systems constitute an intricate immunity network with an important function in bacterial competition.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058911/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058911/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aoki, Stephanie K -- Diner, Elie J -- de Roodenbeke, Claire T'kint -- Burgess, Brandt R -- Poole, Stephen J -- Braaten, Bruce A -- Jones, Allison M -- Webb, Julia S -- Hayes, Christopher S -- Cotter, Peggy A -- Low, David A -- AI043986/AI/NIAID NIH HHS/ -- GM078634/GM/NIGMS NIH HHS/ -- R01 GM078634/GM/NIGMS NIH HHS/ -- U54 AI065359/AI/NIAID NIH HHS/ -- U54 AI065359-056074/AI/NIAID NIH HHS/ -- U54 AI065359-066074/AI/NIAID NIH HHS/ -- U54 AI065359-07/AI/NIAID NIH HHS/ -- U54AI065359/AI/NIAID NIH HHS/ -- England -- Nature. 2010 Nov 18;468(7322):439-42. doi: 10.1038/nature09490.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular, Cellular, and Developmental Biology, University of California - Santa Barbara (UCSB), Santa Barbara, California 93106-9625, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21085179" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Bacterial Toxins/chemistry/genetics/immunology/*metabolism ; Contact Inhibition/immunology/physiology ; Enterobacteriaceae/enzymology/genetics/metabolism ; Escherichia coli Proteins/antagonists & inhibitors/chemistry/genetics/metabolism ; Membrane Proteins/antagonists & inhibitors/chemistry/genetics/metabolism ; Molecular Sequence Data ; Uropathogenic Escherichia coli/enzymology/genetics/growth & ; development/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 10
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    CpG islands influence chromatin structure via the CpG-binding protein Cfp1 (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-04-16
    Description: CpG islands (CGIs) are prominent in the mammalian genome owing to their GC-rich base composition and high density of CpG dinucleotides. Most human gene promoters are embedded within CGIs that lack DNA methylation and coincide with sites of histone H3 lysine 4 trimethylation (H3K4me3), irrespective of transcriptional activity. In spite of these intriguing correlations, the functional significance of non-methylated CGI sequences with respect to chromatin structure and transcription is unknown. By performing a search for proteins that are common to all CGIs, here we show high enrichment for Cfp1, which selectively binds to non-methylated CpGs in vitro. Chromatin immunoprecipitation of a mono-allelically methylated CGI confirmed that Cfp1 specifically associates with non-methylated CpG sites in vivo. High throughput sequencing of Cfp1-bound chromatin identified a notable concordance with non-methylated CGIs and sites of H3K4me3 in the mouse brain. Levels of H3K4me3 at CGIs were markedly reduced in Cfp1-depleted cells, consistent with the finding that Cfp1 associates with the H3K4 methyltransferase Setd1 (refs 7, 8). To test whether non-methylated CpG-dense sequences are sufficient to establish domains of H3K4me3, we analysed artificial CpG clusters that were integrated into the mouse genome. Despite the absence of promoters, the insertions recruited Cfp1 and created new peaks of H3K4me3. The data indicate that a primary function of non-methylated CGIs is to genetically influence the local chromatin modification state by interaction with Cfp1 and perhaps other CpG-binding proteins.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730110/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730110/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thomson, John P -- Skene, Peter J -- Selfridge, Jim -- Clouaire, Thomas -- Guy, Jacky -- Webb, Shaun -- Kerr, Alastair R W -- Deaton, Aimee -- Andrews, Rob -- James, Keith D -- Turner, Daniel J -- Illingworth, Robert -- Bird, Adrian -- 079643/Wellcome Trust/United Kingdom -- 091580/Wellcome Trust/United Kingdom -- 098051/Wellcome Trust/United Kingdom -- G0800026/Medical Research Council/United Kingdom -- Cancer Research UK/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- England -- Nature. 2010 Apr 15;464(7291):1082-6. doi: 10.1038/nature08924.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust Centre for Cell Biology, Michael Swann Building, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20393567" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Brain/cytology ; Cell Line ; Chromatin/*genetics/*metabolism ; *Chromatin Assembly and Disassembly ; Chromatin Immunoprecipitation ; CpG Islands/*genetics ; DNA Methylation ; Genome/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Histones/chemistry/metabolism ; Methylation ; Mice ; NIH 3T3 Cells ; Promoter Regions, Genetic ; Trans-Activators/chemistry/deficiency/genetics/*metabolism ; Zinc Fingers
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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