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  • 1
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    Inhibiting the Self-Sorting Behavior in the Blends of a Homologous Set of Polyurethane Model Compounds (2016)
    American Chemical Society (ACS)
    Details
    Publication Date: 2016-08-20
    Description: The Journal of Physical Chemistry B DOI: 10.1021/acs.jpcb.6b07298
    Electronic ISSN: 1520-5207
    Topics: Chemistry and Pharmacology , Physics
    Published by American Chemical Society (ACS)
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  • 2
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    Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-10-09
    Description: p53 acts as a tumor suppressor by inducing both growth arrest and apoptosis. p53-induced apoptosis can occur without new RNA synthesis through an unknown mechanism. In human vascular smooth muscle cells, p53 activation transiently increased surface Fas (CD95) expression by transport from the Golgi complex. Golgi disruption blocked both p53-induced surface Fas expression and apoptosis. p53 also induced Fas-FADD binding and transiently sensitized cells to Fas-induced apoptosis. In contrast, lpr and gld fibroblasts were resistant to p53-induced apoptosis. Thus, p53 can mediate apoptosis through Fas transport from cytoplasmic stores.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bennett, M -- Macdonald, K -- Chan, S W -- Luzio, J P -- Simari, R -- Weissberg, P -- HL34073/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1998 Oct 9;282(5387):290-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9765154" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptor Proteins, Signal Transducing ; Animals ; Antigens, CD95/genetics/*metabolism ; *Apoptosis/drug effects ; Brefeldin A/pharmacology ; Carrier Proteins/metabolism ; Cell Membrane/*metabolism ; Cells, Cultured ; Enzyme Inhibitors/pharmacology ; Etoposide/pharmacology ; Fas Ligand Protein ; Fas-Associated Death Domain Protein ; Golgi Apparatus/metabolism ; Humans ; Membrane Glycoproteins/genetics/metabolism ; Mice ; Muscle, Smooth, Vascular/cytology ; Mutation ; Protein Synthesis Inhibitors/pharmacology ; Rats ; Topoisomerase II Inhibitors ; Tumor Suppressor Protein p53/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    RNA silencing genes control de novo DNA methylation (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-02-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chan, Simon W-L -- Zilberman, Daniel -- Xie, Zhixin -- Johansen, Lisa K -- Carrington, James C -- Jacobsen, Steven E -- GM60398/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2004 Feb 27;303(5662):1336.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of MCD Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14988555" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/*genetics/growth & development ; Arabidopsis Proteins/*genetics/physiology ; Argonaute Proteins ; Cytosine/metabolism ; *DNA Methylation ; DNA, Plant/metabolism ; Flowers/growth & development ; *Genes, Plant ; Homeodomain Proteins/*genetics ; Mutation ; *RNA Interference ; RNA, Small Interfering/metabolism ; Repetitive Sequences, Nucleic Acid ; Transcription Factors/*genetics ; Transformation, Genetic ; Transgenes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Small interfering RNA-induced transcriptional gene silencing in human cells (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-08-07
    Description: Small interfering RNA (siRNA) and microRNA silence genes at the transcriptional, posttranscriptional, and/or translational level. Using human tissue culture cells, we show that promoter-directed siRNA inhibits transcription of an integrated, proviral, elongation factor 1alpha (EF1A) promoter-green fluorescent protein reporter gene and of endogenous EF1A. Silencing was associated with DNA methylation of the targeted sequence, and it required either active transport of siRNA into the nucleus or permeabilization of the nuclear envelope by lentiviral transduction. These results demonstrate that siRNA-directed transcriptional silencing is conserved in mammals, providing a means to inhibit mammalian gene function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morris, Kevin V -- Chan, Simon W-L -- Jacobsen, Steven E -- Looney, David J -- AI07384/AI/NIAID NIH HHS/ -- P01 AI45992/AI/NIAID NIH HHS/ -- P30 AI36214/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2004 Aug 27;305(5688):1289-92. Epub 2004 Aug 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine 0678, Stein Clinical Research Building, Room 302, University of California-San Diego, La Jolla, CA 92093-0678, USA. kmorris@coh.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15297624" target="_blank"〉PubMed〈/a〉
    Keywords: Active Transport, Cell Nucleus ; Cell Line ; Cell Nucleus/metabolism ; DNA Methylation ; DNA-Binding Proteins/genetics/metabolism ; Down-Regulation ; Eukaryotic Initiation Factor-1/*genetics ; *Gene Silencing ; Genes, Reporter ; Genetic Vectors ; Green Fluorescent Proteins ; Humans ; Immunodeficiency Virus, Feline/genetics ; Luminescent Proteins/biosynthesis/genetics ; Promoter Regions, Genetic ; RNA, Small Interfering/genetics/*metabolism ; Recombinant Fusion Proteins ; Reverse Transcriptase Polymerase Chain Reaction ; *Transcription, Genetic ; Transduction, Genetic ; Transfection ; Transgenes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Synthetic clonal reproduction through seeds (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-02-19
    Description: Cloning through seeds has potential revolutionary applications in agriculture, because it would allow vigorous hybrids to be propagated indefinitely. However, asexual seed formation or apomixis, avoiding meiosis and fertilization, is not found in the major food crops. To develop de novo synthesis of apomixis, we crossed Arabidopsis MiMe and dyad mutants that produce diploid clonal gametes to a strain whose chromosomes are engineered to be eliminated after fertilization. Up to 34% of the progeny were clones of their parent, demonstrating the conversion of clonal female or male gametes into seeds. We also show that first-generation cloned plants can be cloned again. Clonal reproduction through seeds can therefore be achieved in a sexual plant by manipulating two to four conserved genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marimuthu, Mohan P A -- Jolivet, Sylvie -- Ravi, Maruthachalam -- Pereira, Lucie -- Davda, Jayeshkumar N -- Cromer, Laurence -- Wang, Lili -- Nogue, Fabien -- Chan, Simon W L -- Siddiqi, Imran -- Mercier, Raphael -- New York, N.Y. -- Science. 2011 Feb 18;331(6019):876. doi: 10.1126/science.1199682.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research (CSIR), Hyderabad, India.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21330535" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/*genetics/*physiology ; Chromosome Segregation/genetics ; Chromosomes, Plant ; Crosses, Genetic ; Diploidy ; Genes, Plant ; *Genetic Engineering ; Heterozygote ; Histones/genetics ; Meiosis/genetics ; Plant Proteins/genetics ; Plants, Genetically Modified ; Reproduction, Asexual ; Seeds/*genetics/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Haploid plants produced by centromere-mediated genome elimination (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-03-26
    Description: Production of haploid plants that inherit chromosomes from only one parent can greatly accelerate plant breeding. Haploids generated from a heterozygous individual and converted to diploid create instant homozygous lines, bypassing generations of inbreeding. Two methods are generally used to produce haploids. First, cultured gametophyte cells may be regenerated into haploid plants, but many species and genotypes are recalcitrant to this process. Second, haploids can be induced from rare interspecific crosses, in which one parental genome is eliminated after fertilization. The molecular basis for genome elimination is not understood, but one theory posits that centromeres from the two parent species interact unequally with the mitotic spindle, causing selective chromosome loss. Here we show that haploid Arabidopsis thaliana plants can be easily generated through seeds by manipulating a single centromere protein, the centromere-specific histone CENH3 (called CENP-A in human). When cenh3 null mutants expressing altered CENH3 proteins are crossed to wild type, chromosomes from the mutant are eliminated, producing haploid progeny. Haploids are spontaneously converted into fertile diploids through meiotic non-reduction, allowing their genotype to be perpetuated. Maternal and paternal haploids can be generated through reciprocal crosses. We have also exploited centromere-mediated genome elimination to convert a natural tetraploid Arabidopsis into a diploid, reducing its ploidy to simplify breeding. As CENH3 is universal in eukaryotes, our method may be extended to produce haploids in any plant species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ravi, Maruthachalam -- Chan, Simon W L -- England -- Nature. 2010 Mar 25;464(7288):615-8. doi: 10.1038/nature08842.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Biology, University of California, Davis, Davis, California 95616, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20336146" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/*genetics/*metabolism ; Cell Nucleus/genetics ; Centromere/*metabolism ; Crosses, Genetic ; Diploidy ; Genome, Plant/*genetics ; *Haploidy ; Histones/*genetics/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 7
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    Theoretical Modelling of Sound Radiation from Plate (2017)
    Institute of Physics (IOP)
    Details
    Publication Date: 2017-01-13
    Description: Recently the development of aerospace, automotive and building industries demands the use of lightweight materials such as thin plates. However, the plates can possibly add to significant vibration and sound radiation, which eventually lead to increased noise in the community. So, in this study, the fundamental concept of sound pressure radiated from a simply-supported thin plate (SSP) was analyzed using the derivation of mathematical equations and numerical simulation of ANSYS®. The solution to mathematical equations of sound radiated from a SSP was visualized using MATLAB®. The responses of sound pressure level were measured at far field as well as near field in the frequency range of 0–200 Hz. Result shows that there are four resonance frequencies; 12 Hz, 60 Hz, 106 Hz and 158 Hz were identified which represented by the total number of the peaks in the frequency response function graph. The outcome also indicates that the mathematical derivation correlated well with the simul...
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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  • 8
    Electronic Resource
    Electronic Resource
    Epitaxy of Y-Ba-Cu-O thin films grown on single-crystal MgO (1990)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 56 (1990), S. 2243-2245 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The epitaxy of a thin-film Y-Ba-Cu-O (YBCO) superconductor deposited on a single-crystal [001] MgO substrate was examined by transmission electron microscopy. The large lattice mismatch (8–10%) in the basal plane of YBCO and MgO is accommodated mainly by the formation of a polycrystalline, mosaic structure. The grain boundaries correspond to unique crystallographic interfaces, determined by the crystal symmetry of the substrate and the thin film.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.102932
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  • 9
    Electronic Resource
    Electronic Resource
    Degenerate epitaxy, coincidence epitaxy and origin of ''special'' boundaries in thin films
    Amsterdam : Elsevier
    Journal of Physics and Chemistry of Solids 55 (1994), S. 1137-1145 
    Details
    ISSN: 0022-3697
    Keywords: A. interfaces ; A. superconductors ; A. thin films ; B. epitaxial growth ; D. microstructure
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-3697(94)90131-7
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  • 10
    Electronic Resource
    Electronic Resource
    Nature of grain boundaries as related to critical currents in superconducting YBa"2Cu"3O"7" "-" "x
    Amsterdam : Elsevier
    Journal of Physics and Chemistry of Solids 55 (1994), S. 1415-1432 
    Details
    ISSN: 0022-3697
    Keywords: A. interfaces ; A. superconductors ; C. electron microscopy ; D. critical phenomena ; D. defects ; D. transport properties
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0022-3697(94)90568-1
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