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Conjugate Divergent Margins (2013)

Geological Society (London, U.K.) ; Mohriak, W. U. ; Danforth, A. ; [et al.]

London : The Geological Society

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Description / Table of Contents: The main focus of the book is the geological and geophysical interpretation of sedimentary basins along the South, Central and North Atlantic conjugate margins, but concepts derived from physical models, outcrop analogues and present-day margins are also discussed in some chapters. There is an encompassing description of several conjugate margins worldwide, based on recent geophysical and geological datasets. An overview of important aspects related to the geodynamic development and petroleum geology of Atlantic-type sedimentary basins is also included. Several chapters analyse genetic mechanisms and break-up processes associated with rift-phase structures and salt tectonics, providing a full description of conjugate margin basins based on deep seismic profiles and potential field methods.

Pages: Online-Ressource (VII, 568 Seiten)

ISBN: 9781862393493

URL: http://sp.lyellcollection.org/content/369/1.toc

Language: English

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Transform Margins: Development, Controls and Petroleum Systems (2016)

Geological Society (London, U.K.) ; Nemčok, M. ; Rybár, S. ; [et al.]

London : The Geological Society

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Description / Table of Contents: This volume covers the linkage between new transform margin research and increasing transform margin exploration. It offers a critical set of predictive tools via an understanding of the mechanisms involved in the development of play concept elements at transform margins. It ties petroleum systems knowledge to the input coming from research focused on dynamic development, kinematic development, structural architecture and thermal regimes, together with their controlling factors. The volume does this by drawing from geophysical data (bathymetry, seismic, gravity and magnetic studies), structural geology, sedimentology, geochemistry, plate reconstruction and thermo-mechanical numerical modelling. It combines case studies (covering the Andaman Sea, Arctic, Coromandal, Guyana, Romanche, St. Paul and Suriname transform margins, the French Guyana hyper-oblique margin, the transtensional margin between the Caribbean and North American plates, and the Davie transform margin and its neighbour transform margins) with theoretical studies.

Pages: Online-Ressource (385 Seiten)

ISBN: 9781862397446

URL: http://sp.lyellcollection.org/content/431/1.toc

Language: English

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Transform margins: development, controls and petroleum systems - an introduction (2016)

Nemcok, M., Rybar, S., Sinha, S. T., Hermeston, S. A., Ledvenyiova, L.

Geological Society (of London)

In: Special Publications / Geological Society London

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Publication Date: 2016-07-16

Description: This paper provides an overview of the existing knowledge of transform margins including their dynamic development, kinematic development, structural architecture and thermal regime, together with the factors controlling these. This systematic knowledge is used for describing predictive models of various petroleum system concept elements such as source rock, seal rock and reservoir rock distribution, expulsion timing, trapping style and timing, and migration patterns. The paper then introduces individual contributions to this volume and their focus. Supplementary material: Location table and map of specific transform examples, structural elements of the Romanche transform margin and glossary of terms used in this article is available at https://doi.org/10.6084/m9.figshare.c.3276407

Print ISSN: 0305-8719

Electronic ISSN: 2041-4927

Topics: Geosciences

Published by Geological Society (of London)

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Enzyme encapsulation into microcompartments [Microbiology] (2012)

Fan, C., Cheng, S., Sinha, S., Bobik, T. A.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2012-09-12

Description: Bacterial microcompartments (MCPs) are a widespread family of proteinaceous organelles that consist of metabolic enzymes encapsulated within a protein shell. For MCPs to function specific enzymes must be encapsulated. We recently reported that a short N-terminal targeting sequence of propionaldehyde dehydrogenase (PduP) is necessary and sufficient for the packaging of...

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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Evidence for Deep Regulatory Similarities in Early Developmental Programs across Highly Diverged Insects (2014)

Kazemian, M., Suryamohan, K., Chen, J.-Y., Zhang, Y., Samee, M. A. H., Halfon, M. S., Sinha, S.

Oxford University Press

In: Genome Biology and Evolution

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Publication Date: 2014-09-19

Description: Many genes familiar from Drosophila development, such as the so-called gap, pair-rule, and segment polarity genes, play important roles in the development of other insects and in many cases appear to be deployed in a similar fashion, despite the fact that Drosophila -like "long germband" development is highly derived and confined to a subset of insect families. Whether or not these similarities extend to the regulatory level is unknown. Identification of regulatory regions beyond the well-studied Drosophila has been challenging as even within the Diptera (flies, including mosquitoes) regulatory sequences have diverged past the point of recognition by standard alignment methods. Here, we demonstrate that methods we previously developed for computational cis -regulatory module (CRM) discovery in Drosophila can be used effectively in highly diverged (250–350 Myr) insect species including Anopheles gambiae , Tribolium castaneum , Apis mellifera , and Nasonia vitripennis . In Drosophila , we have successfully used small sets of known CRMs as "training data" to guide the search for other CRMs with related function. We show here that although species-specific CRM training data do not exist, training sets from Drosophila can facilitate CRM discovery in diverged insects. We validate in vivo over a dozen new CRMs, roughly doubling the number of known CRMs in the four non- Drosophila species. Given the growing wealth of Drosophila CRM annotation, these results suggest that extensive regulatory sequence annotation will be possible in newly sequenced insects without recourse to costly and labor-intensive genome-scale experiments. We develop a new method, Regulus, which computes a probabilistic score of similarity based on binding site composition (despite the absence of nucleotide-level sequence alignment), and demonstrate similarity between functionally related CRMs from orthologous loci. Our work represents an important step toward being able to trace the evolutionary history of gene regulatory networks and defining the mechanisms underlying insect evolution.

Electronic ISSN: 1759-6653

Topics: Biology

Published by Oxford University Press

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Genome-Wide Screen Reveals sec21 Mutants of Saccharomyces cerevisiae Are Methotrexate-Resistant (2017)

Wong, L. H., Flibotte, S., Sinha, S., Chiang, J., Giaever, G., Nislow, C.

Genetics Society of America (GSA)

In: G3: Genes, Genomes, Genetics

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Publication Date: 2017-04-14

Description: Drug resistance is a consequence of how most modern medicines work. Drugs exert pressure on cells that causes death or the evolution of resistance. Indeed, highly specific drugs are rendered ineffective by a single DNA mutation. In this study, we apply the drug methotrexate, which is widely used in cancer and rheumatoid arthritis, and perform evolution experiments on Baker’s yeast to ask the different ways in which cells become drug resistant. Because of the conserved nature of biological pathways between yeast and man, our results can inform how the same mechanism may operate to render human cells resistant to treatment. Exposure of cells to small molecules and drug therapies imposes a strong selective pressure. As a result, cells rapidly acquire mutations in order to survive. These include resistant variants of the drug target as well as those that modulate drug transport and detoxification. To systematically explore how cells acquire drug resistance in an unbiased manner, rapid cost-effective approaches are required. Methotrexate, as one of the first rationally designed anticancer drugs, has served as a prototypic example of such acquired resistance. Known methotrexate resistance mechanisms include mutations that increase expression of the dihydrofolate reductase (DHFR) target as well as those that maintain function yet reduce the drug’s binding affinity. Recent evidence suggests that target-independent, epistatic mutations can also result in resistance to methotrexate. Currently, however, the relative contribution of such unlinked resistance mutations is not well understood. To address this issue, we took advantage of Saccharomyces cerevisiae as a model eukaryotic system that combined with whole-genome sequencing and a rapid screening methodology, allowed the identification of causative mutations that modulate resistance to methotrexate. We found a recurrent missense mutation in SEC21 (orthologous to human COPG1), which we confirmed in 10 de novo methotrexate-resistant strains. This sec21 allele (S96L) behaves as a recessive, gain-of-function allele, conferring methotrexate resistance that is abrogated by the presence of a wild-type copy of SEC21 . These observations indicate that the Sec21p /COPI transport complex has previously uncharacterized roles in modulating methotrexate stress.

Electronic ISSN: 2160-1836

Topics: Biology

Published by Genetics Society of America (GSA)

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First identification of excited states in ^{117} Ba using the recoil-β-delayed proton tagging technique (2017)

B. Ding, Z. Liu, D. Seweryniak, P. J. Woods, H. L. Wang, J. Yang, H. L. Liu, C. N. Davids, M. P. Carpenter, T. Davinson, R. V. F. Janssens, R. D. Page, A. P. Robinson, J. Shergur, S. Sinha, S. Zhu, X. D. Tang, J. G. Wang, T. H. Huang, W. Q. Zhang, M. D. Sun, X. Y. Liu, and H. Y. Lu

American Physical Society (APS)

In: Physical Review C

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Publication Date: 2017-02-02

Description: Author(s): B. Ding, Z. Liu, D. Seweryniak, P. J. Woods, H. L. Wang, J. Yang, H. L. Liu, C. N. Davids, M. P. Carpenter, T. Davinson, R. V. F. Janssens, R. D. Page, A. P. Robinson, J. Shergur, S. Sinha, S. Zhu, X. D. Tang, J. G. Wang, T. H. Huang, W. Q. Zhang, M. D. Sun, X. Y. Liu, and H. Y. Lu Excited states have been observed for the first time in the neutron-deficient nucleus Ba 117 using the recoil-decay tagging technique following the heavy-ion fusion-evaporation reaction Zn 64 ( Ni 58 , 2p3n) Ba 117 . Prompt γ rays have been assigned to Ba 117 through correlations with β -delayed protons follow… [Phys. Rev. C 95, 024301] Published Wed Feb 01, 2017

Keywords: Nuclear Structure

Print ISSN: 0556-2813

Electronic ISSN: 1089-490X

Topics: Physics

Published by American Physical Society (APS)

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8

Electronic Resource

Spatial Modeling for Base-Metal Mineral Exploration Through Integration of Geological Data Sets (2000)

Venkataraman, G. ; Madhavan, B. Babu ; Ratha, D. S. ; [et al.]

Springer

Natural resources research 9 (2000), S. 27-42

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ISSN: 1573-8981

Keywords: Spatial modeling ; mineral exploration ; Bayesian statistics ; fuzzy logic

Source: Springer Online Journal Archives 1860-2000

Topics: Geosciences

Notes: Abstract This study involves the integration of information interpreted from data sets such as LandsatTM, Airborne magnetic, geochemical, geological, and ground-based data of Rajpura—Dariba,Rajasthan, India through GIS with the help of (1) Bayesian statistics based on the weights ofevidence method and (2) a fuzzy logic algorithm to derive spatial models to target potentialbase-metal mineralized areas for future exploration. Of the 24 layers considered, five layers(graphite mica schist (GMS), calc-silicate marble (CALC), NE-SW lineament 0–2000 mcorridor (L4-NESW), Cu 200–250 ppm, and Pb 200–250 ppm) have been identified from theBayesian approach on the basis of contrast. Thus, unique conditions were formed based onthe presence and absence of these five map patterns, which are converted to estimate posteriorprobabilities. The final map, based on the same data used to determine the relationships, showsfour classes of potential zones of sulfide mineralization on the basis of posterior probability.In the fuzzy set approach, membership functions of the layers such as CALC, GMS, NE-SWlineament corridor maps, Pb, and Cu geochemical maps have been integrated to obtain thefinal potential map showing four classes of favorability index.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1010157613023

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