Publication Date:
2016-07-31
Description:
Article Ephrins are transmembrane proteins involved in cell-cell communication, and implicated in cancer cell growth and progression. Here, the authors show that EphrinB2 expression is reduced in glioma cells both by genetic and epigenetic alterations and under hypoxia, through a HIF1α-mediated direct regulation of ZEB2, which enhances invasion and anti-angiogenic resistance. Nature Communications doi: 10.1038/ncomms12329 Authors: C. Depner, H. zum Buttel, N. Böğürcü, A. M. Cuesta, M. R. Aburto, S. Seidel, F. Finkelmeier, F. Foss, J. Hofmann, K. Kaulich, S. Barbus, M. Segarra, G. Reifenberger, B. K. Garvalov, T. Acker, A. Acker-Palmer
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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