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  • 1
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    Transcription activator like effector (TALE)-directed piggyBac transposition in human cells (2013)
    Oxford University Press
    Details
    Publication Date: 2013-10-19
    Description: Insertional therapies have shown great potential for combating genetic disease and safer methods would undoubtedly broaden the variety of possible illness that can be treated. A major challenge that remains is reducing the risk of insertional mutagenesis due to random insertion by both viral and non-viral vectors. Targetable nucleases are capable of inducing double-stranded breaks to enhance homologous recombination for the introduction of transgenes at specific sequences. However, off-target DNA cleavages at unknown sites can lead to mutations that are difficult to detect. Alternatively, the piggyBac transposase is able perform all of the steps required for integration; therefore, cells confirmed to contain a single copy of a targeted transposon, for which its location is known, are likely to be devoid of aberrant genomic modifications. We aimed to retarget transposon insertions by comparing a series of novel hyperactive piggyBac constructs tethered to a custom transcription activator like effector DNA-binding domain designed to bind the first intron of the human CCR5 gene. Multiple targeting strategies were evaluated using combinations of both plasmid-DNA and transposase-protein relocalization to the target sequence. We demonstrated user-defined directed transposition to the CCR5 genomic safe harbor and isolated single-copy clones harboring targeted integrations.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 2
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    Multiple daily amphetamine administration: behavioral and neurochemical alterations (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-22
    Description: In rats, multiple daily amphetamine injections (2.5 milligrams per kilogram of body weight, injected subcutaneously every 4 hours for 5 days) resulted in a progressive augmentation in response, characterized by a more rapid onset and an increased magnitude of stereotypy. By contrast, offset times of both the stereotypy and the poststereotypy hyperactivity periods were markedly shortened. When the animals were retested with the same dose of amphetamine 8 days after the long-term treatment was discontinued, the time of offset of the stereotypy and hyperactivity phases had recovered to values found with short-term amphetamine treatment, whereas the more rapid onset of stereotypy persisted. Brain monoamine and amphetamine concentrations and tyrosine hydroxylase activity were determined in comparably treated rats at times corresponding to the behavioral observations. The behavioral data indicate that enhanced responsiveness to amphetamine following its repeated administration may contribute to the development of amphetamine psychosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Segal, D S -- Weinberger, S B -- Cahill, J -- McCunney, S J -- New York, N.Y. -- Science. 1980 Feb 22;207(4433):904-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17729873" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Multiple daily amphetamine administration: behavioral and neurochemical alterations (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-15
    Description: In rats, multiple daily amphetamine injections (2.5 milligrams per kilogram of body weight, injected subcutaneously every 4 hours for 5 days) resulted in a progressive augmentation in response, characterized by a more rapid onset and an increased magnitude of stereotypy. By contrast, offset times of both the stereotypy and the poststereotypy hyperactivity periods were markedly shortened. When the animals were retested with the same dose of amphetamine 8 days after the long-term treatment was discontinued, the time of offset of the stereotypy and hyperactivity phases had recovered to values found with short-term amphetamine treatment, whereas the more rapid onset of stereotypy persisted. Brain monoamine and amphetamine concentrations and tyrosine hydroxylase activity were determined in comparably treated rats at times corresponding to the behavioral observations. The behavioral data indicate that enhanced responsiveness to amphetamine following its repeated administration may contribute to the development of amphetamine psychosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Segal, D S -- Weinberger, S B -- Cahill, J -- McCunney, S J -- New York, N.Y. -- Science. 1980 Feb 15;207(4433):905-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7188815" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior/*drug effects ; Behavior, Animal/*drug effects ; Brain/metabolism ; Brain Chemistry/drug effects ; Dextroamphetamine/administration & dosage/*pharmacology ; Dopamine/metabolism ; Dose-Response Relationship, Drug ; Humans ; Male ; Motor Activity/drug effects ; Norepinephrine/metabolism ; Rats ; Serotonin/metabolism ; Stereotyped Behavior/*drug effects ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    The fanconi syndrome in Basenji dogs: a new model for renal transport defects (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-22
    Description: The renal defects resulting in a Fanconi syndrome were seen in eight Basenji dogs by measuring renal clearance and in vitro amino acid and sugar uptake and performing histopathologic evaluations. Renal tubular handling of glucose, phosphate, sodium, potassium, uric acid, and amino acids was abnormal, and in vitro uptake of labeled lysine, glycine, and alpha-methyl-D-glucoside by renal cortical slices was impaired. Histopathology was normal except for enlarged nuclei in some renal tubule cells. These Basenji dogs, which may be genetically affected, represent a likely model for idiopathic Fanconi syndrome in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bovee, K C -- Joyce, T -- Reynolds, R -- Segal, S -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1129-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684432" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/metabolism ; Animals ; *Disease Models, Animal ; Dog Diseases/*metabolism/pathology ; Dogs ; Fanconi Syndrome/metabolism/pathology/*veterinary ; Female ; Glomerular Filtration Rate ; Glucose/metabolism ; Kidney Tubules/metabolism/pathology ; Male ; Metabolic Clearance Rate ; Phosphates/metabolism ; Potassium/metabolism ; Sodium/metabolism ; Uric Acid/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Cystinuria in the maned wolf of South America (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-22
    Description: Of 42 maned wolves in zoos or live-trapped in Brazil, 34 had excessive cystine in their urine. Renal clearance studies of five of the affected wolves revealed a variable defect for the reabsorption of cystine and dibasic amino acids. The renal tubular handling of other solutes including glucose, phosphate, sodium, potassium, and uric acid was considered normal. Urinary calculi composed of cystine were found in four wolves and proved fatal in three of them. With the exception of the high incidence in this species, this hereditary disease resembles the disorder described in dogs and humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bovee, K C -- Bush, M -- Dietz, J -- Jezyk, P -- Segal, S -- AM 10894/AM/NIADDK NIH HHS/ -- GM 20138/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1981 May 22;212(4497):919-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233184" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/metabolism ; Animals ; Animals, Zoo/*urine ; Carnivora/*metabolism ; Cystine/metabolism ; Cystinuria/*veterinary ; Kidney/metabolism ; Kidney Tubules/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Flow control among microvessels coordinated by intercellular conduction (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-11-14
    Description: Optimal distribution of blood flow requires coordination of vasodilation among resistance vessels. During hyperemia, blood vessels dilate upstream from the initiating stimulus. Spreading vasodilation independent of flow changes has not been previously demonstrated. In the present study, iontophoresis of acetylcholine adjacent to single hamster cheek pouch arterioles in situ (diameter, 20 to 37 micrometers) induced a rapid bidirectional dilation that was not attenuated when blood flow was eliminated with vascular occlusion. This finding indicates that a vasodilatory stimulus is conducted along the arteriole and demonstrates the existence of a mechanism of intercellular communication that is capable of coordinating diameter changes among resistance vessels.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Segal, S S -- Duling, B R -- HL06947/HL/NHLBI NIH HHS/ -- HL12792/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1986 Nov 14;234(4778):868-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3775368" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/*pharmacology ; Animals ; Arterioles/physiology ; Blood Flow Velocity ; Cell Communication ; Cheek/blood supply ; Cricetinae ; Iontophoresis ; Vascular Resistance ; Vasodilation/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    From damage to discovery via virtual unwrapping: Reading the scroll from En-Gedi (2016)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2016-09-23
    Description: Computer imaging techniques are commonly used to preserve and share readable manuscripts, but capturing writing locked away in ancient, deteriorated documents poses an entirely different challenge. This software pipeline—referred to as "virtual unwrapping"—allows textual artifacts to be read completely and noninvasively. The systematic digital analysis of the extremely fragile En-Gedi scroll (the oldest Pentateuchal scroll in Hebrew outside of the Dead Sea Scrolls) reveals the writing hidden on its untouchable, disintegrating sheets. Our approach for recovering substantial ink-based text from a damaged object results in readable columns at such high quality that serious critical textual analysis can occur. Hence, this work creates a new pathway for subsequent textual discoveries buried within the confines of damaged materials.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Immune-mediated CNS axon regeneration [Neuroscience] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-02-26
    Description: Innate immunity can facilitate nervous system regeneration, yet the underlying cellular and molecular mechanisms are not well understood. Here we show that intraocular injection of lipopolysaccharide (LPS), a bacterial cell wall component, or the fungal cell wall extract zymosan both lead to rapid and comparable intravitreal accumulation of blood-derived myeloid...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 9
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    Een vooronderzoek naar de systematische positie van Juncus ambiguus Guss (1960)
    In:  Correspondentieblad ten dienste van de floristiek en het vegetatie-onderzoek van Nederland vol.16 (1960) nr.1 p.169
    Details
    Publication Date: 2015-05-08
    Description: De door Linnaeus (1753) beschreven Juncus bufonius L. is een soort die de gemoederen van vele botanici in opstand heeft gebracht. Het is gebleken, dat er een aantal verwante taxa zijn waarvan de systematische betekenis nooit geheel duidelijk is geworden. Vele botanici hebben zich dan ook beijverd nieuwe soorten te beschrijven, anderen durfden dit niet aan en beschreven de van de typische J. bufonius afwijkende planten als ondersoorten of variëteiten van J. bufonius. Tot deze afwijkende typen behoren J. foliosus Desf., J. sphaerocarpus Nees, J. sorrentinii Parlat. (een Sardico-Siciliaans endeem), J. mutabilis Savi, J. ranarius Song. & Perr. en J. ambiguus Guss., elk met een aantal synoniemen. J. foliosus (vlakke, tot 2 mm brede bladeren) en J. sphaerocarpus (bloemen klein, met 2-3 mm lange bloemdekbladen en kogelronde vruchtbeginsels) staan geheel apart en zijn beide zonder enige twijfel goede soorten, of eventueel “kleine soorten” binnen de collectiefsoort J. bufonius L. Ook J. sorrentinii is een duidelijk van de andere vormen te onderscheiden type (zeer lang onderst schutblad, meestal veel, zelfs tot 20 bloemen bijeen in een waaiervormige bloeiwijze, bloemdekbladen tweemaal zo lang als het vruchtbeginsel).
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
    Format: application/pdf
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  • 10
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    Het geslacht Parietaria L. in Nederland, 1 (1967)
    In:  Gorteria: tijdschrift voor de floristiek, de plantenoecologie en het vegetatie-onderzoek van Nederland vol. 3 no. 7, pp. 96-102
    Details
    Publication Date: 2024-01-12
    Description: A summary will be given at the end of part 2 of this paper.
    Repository Name: National Museum of Natural History, Netherlands
    Type: info:eu-repo/semantics/article
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