Publication Date:
1983-08-19
Description:
Aerobic organisms depend on superoxide dismutase to suppress the formation of dangerous species of activated oxygen. Intraerythrocytic stages of the malaria parasite exist within a highly aerobic environment and cause the generation of increased amounts of activated oxygen. Plasmodium berghei in mice was found to derive a substantial amount of superoxide dismutase activity from the host cell cytoplasm. Plasmodia isolated from mouse red cells contained mouse superoxide dismutase, whereas rat-derived parasites contained the rat enzyme. This is believed to be the first example of the acquisition of a host cell enzyme by an intracellular parasite.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fairfield, A S -- Meshnick, S R -- Eaton, J W -- AI 16975/AI/NIAID NIH HHS/ -- HL 16833/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):764-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6348944" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Erythrocytes/enzymology/parasitology
;
Isoelectric Point
;
Malaria/*enzymology
;
Mice
;
Plasmodium berghei/*enzymology
;
Superoxide Dismutase/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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