Publication Date:
1986-04-04
Description:
An electrophysiological stimulation paradigm similar to one that produces Pavlovian conditioning was applied to synaptic inputs to pyramidal neurons of hippocampal brain slices. Persistent synaptic enhancement was induced in one of two weak synaptic inputs by pairing high-frequency electrical stimulation of the weak input with stimulation of a third, stronger input to the same region. Forward (temporally overlapping) but not backward (temporally separate) pairings caused this enhancement. Thus hippocampal synapses in vitro can undergo the conditional and selective type of associative modification that could provide the substrate for some of the mnemonic functions in which the hippocampus is thought to participate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kelso, S R -- Brown, T H -- NS07408/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1986 Apr 4;232(4746):85-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3952501" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Conditioning, Classical
;
Electric Stimulation
;
Hippocampus/*physiology
;
In Vitro Techniques
;
Models, Neurological
;
Models, Psychological
;
Neurons/physiology
;
Pyramidal Tracts/physiology
;
Rats
;
Synapses/*physiology
;
Time Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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