ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

1

Unknown

ErbB2-intronic MicroRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling (2015)

D C Schmitt; L Madeira da Silva; W Zhang; Z Liu; R Arora; S Lim; A M Schuler; S McClellan; J F Andrews; A G Kahn; M Zhou; E-YE Ahn; M Tan

Springer Nature

In: Cell Death & Disease

add to mindlist on the mindlist

Details

Publication Date: 2015-05-08

Description: ErbB2-intronic MicroRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling Cell Death and Disease 6, e1742 (May 2015). doi:10.1038/cddis.2015.116 Authors: D C Schmitt, L Madeira da Silva, W Zhang, Z Liu, R Arora, S Lim, A M Schuler, S McClellan, J F Andrews, A G Kahn, M Zhou, E-YE Ahn & M Tan

Electronic ISSN: 2041-4889

Topics: Biology , Medicine

Published by Springer Nature

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

PAPER CURRENT

S·F·X

Fulltext

2

Unknown

In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium (1995)

D. L. Kooyman ; G. W. Byrne ; S. McClellan ; [et al.]

American Association for the Advancement of Science (AAAS)

In: Science. 269(5220): 89-92.

add to mindlist on the mindlist

Details

Publication Date: 1995-07-07

Description: Many proteins are associated with the outer layer of the cell membrane through a posttranslationally added glycosyl phosphatidylinositol (GPI) anchor. The functional significance of this type of protein linkage is unclear, although it results in increased lateral mobility, sorting to the apical surface of the cell, reinsertion into cell membranes, and possibly cell signaling. Here evidence is presented that GPI-linked proteins can undergo intermembrane transfer in vivo. GPI-linked proteins expressed on the surface of transgenic mouse red blood cells were transferred in a functional form to endothelial cells in vivo. This feature of GPI linkage may be potentially useful for the delivery of therapeutic proteins to vascular endothelium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kooyman, D L -- Byrne, G W -- McClellan, S -- Nielsen, D -- Tone, M -- Waldmann, H -- Coffman, T M -- McCurry, K R -- Platt, J L -- Logan, J S -- HL 46810/HL/NHLBI NIH HHS/ -- HL 50985/HL/NHLBI NIH HHS/ -- HL 52297/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1995 Jul 7;269(5220):89-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sir William Dunn School of Pathology, Oxford, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7541557" target="_blank"〉PubMed〈/a〉

Keywords: Animals ; Antigens, CD/genetics/*metabolism ; Antigens, CD55 ; Antigens, CD59 ; Base Sequence ; Bone Marrow Transplantation ; Cell Membrane/metabolism ; Cells, Cultured ; Complement Inactivator Proteins/genetics/*metabolism ; Endothelium, Vascular/cytology/*metabolism ; Erythrocytes/*metabolism ; Globins/genetics ; Glycosylphosphatidylinositols/*metabolism ; Humans ; Membrane Glycoproteins/genetics/*metabolism ; Mice ; Mice, Transgenic ; Molecular Sequence Data ; Myocardium/metabolism

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

Published by American Association for the Advancement of Science (AAAS)

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

PAPER CURRENT

S·F·X

Fulltext

3

Unknown

iFUSE: integrated fusion gene explorer (2013)

Hiltemann, S., McClellan, E. A., van Nijnatten, J., Horsman, S., Palli, I., Teles Alves, I., Hartjes, T., Trapman, J., van der Spek, P., Jenster, G., Stubbs, A.

Oxford University Press

In: Bioinformatics

add to mindlist on the mindlist

Details

Publication Date: 2013-06-24

Description: : We present iFUSE (integrated fusion gene explorer), an online visualization tool that provides a fast and informative view of structural variation data and prioritizes those breaks likely representing fusion genes. This application uses calculated break points to determine fusion genes based on the latest annotation for genomic sequence information, and where relevant the structural variation (SV) events are annotated with predicted RNA and protein sequences. iFUSE takes as input a Complete Genomics (CG) junction file, a FusionMap fusion detection report file or a file already analysed and annotated by the iFUSE application on a previous occasion. Results: We demonstrate the use of iFUSE with case studies from tumour-normal SV detection derived from Complete Genomics whole-genome sequencing results. Availability: iFUSE is available as a web service at http://ifuse.erasmusmc.nl . Contact: s.hiltemann@erasmusmc.nl or a.stubbs@erasmusmc.nl

Print ISSN: 1367-4803

Electronic ISSN: 1460-2059

Topics: Biology , Computer Science , Medicine

Published by Oxford University Press

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

PAPER CURRENT

S·F·X

Fulltext

4

Unknown

Seawater carbonate chemistry and growth and physiology of the marine cyanobacterium Synechococcus (Cyanophyceae) (2022)

Laws, Edward A ; McClellan, S Alex

PANGAEA

add to mindlist on the mindlist

Details

Publication Date: 2024-03-15

Description: The marine cyanobacterium Synechococcus elongatus was grown in a continuous culture system to study the interactive effects of temperature, irradiance, nutrient limitation, and the partial pressure of CO2 (pCO2) on its growth and physiological characteristics. Cells were grown on a 14:10 h light:dark cycle at all combinations of low and high irradiance (50 and 300 μmol photons/m**2/s, respectively), low and high pCO2 (400 and 1000 ppmv, respectively), nutrient limitation (nitrate-limited and nutrient-replete conditions), and temperatures of 20–45°C in 5°C increments. The maximum growth rate was ~4.5 · d−1 at 30–35°C. Under nutrient-replete conditions, growth rates at most temperatures and irradiances were about 8% slower at a pCO2 of 1000 ppmv versus 400 ppmv. The single exception was 45°C and high irradiance. Under those conditions, growth rates were ~45% higher at 1000 ppmv. Cellular carbon:nitrogen ratios were independent of temperature at a fixed relative growth rate but higher at high irradiance than at low irradiance. Initial slopes of photosynthesis–irradiance curves were higher at all temperatures under nutrient-replete versus nitrate-limited conditions; they were similar at all temperatures under high and low irradiance, except at 20°C, when they were suppressed at high irradiance. A model of phytoplankton growth in which cellular carbon was allocated to structure, storage, or the light or dark reactions of photosynthesis accounted for the general patterns of cell composition and growth rate. Allocation of carbon to the light reactions of photosynthesis was consistently higher at low versus high light and under nutrient-replete versus nitrate-limited conditions.

Keywords: Alkalinity, total; Aragonite saturation state; Bacteria; Bicarbonate; Bicarbonate ion; Biomass/Abundance/Elemental composition; Bottles or small containers/Aquaria (〈20 L); Calcite saturation state; Calculated using seacarb after Nisumaa et al. (2010); Carbon, inorganic, dissolved; Carbon/Chlorophyll a ratio; Carbon/Nitrogen ratio; Carbonate ion; Carbonate system computation flag; Carbon dioxide; Carbon dioxide, dissolved; Cyanobacteria; Fugacity of carbon dioxide (water) at sea surface temperature (wet air); Growth/Morphology; Growth rate; Initial slope of the photosynthesis-irradiance curve; Irradiance; Laboratory experiment; Laboratory strains; Light; Macro-nutrients; Not applicable; OA-ICC; Ocean Acidification International Coordination Centre; Partial pressure of carbon dioxide (water) at sea surface temperature (wet air); Pelagos; pH; Photosynthetic carbon fixation rate, per chlorophyll a; Phytoplankton; Primary production/Photosynthesis; Ratio; Salinity; Single species; Species, unique identification; Species, unique identification (Semantic URI); Species, unique identification (URI); Synechococcus elongatus; Temperature; Temperature, water; Treatment; Type

Type: Dataset

Format: text/tab-separated-values, 1392 data points

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

DATA PANGAEA

S·F·X

Fulltext

5

Unknown

Seawater carbonate chemistry and growth and physiology of the marine diatom Thalassiosira pseudonana (Coscinodiscophyceae) (2020)

Laws, Edward A ; McClellan, S Alex

PANGAEA

add to mindlist on the mindlist

Details

Publication Date: 2024-03-18

Description: The marine diatom Thalassiosira pseudonana was grown in continuous culture systems to study the interactive effects of temperature, irradiance, nutrient limitation, and the partial pressure of CO2 (pCO2) on its growth and physiological characteristics. The cells were able to grow at all combinations of low and high irradiance (50 and 300 μmol photons/m**2/ s, respectively, of visible light), low and high pCO2 (400 and 1,000 μatm, respectively), nutrient limitation (nitrate‐limited and nutrient‐replete conditions), and temperatures of 10–32°C. Under nutrient‐replete conditions, there was no adverse effect of high pCO2 on growth rates at temperatures of 10–25°C. The response of the cells to high pCO2 was similar at low and high irradiance. At supraoptimal temperatures of 30°C or higher, high pCO2 depressed growth rates at both low and high irradiance. Under nitrate‐limited conditions, cells were grown at 38 ± 2.4% of their nutrient‐saturated rates at the same temperature, irradiance, and pCO2. Dark respiration rates consistently removed a higher percentage of production under nitrate‐limited versus nutrient‐replete conditions. The percentages of production lost to dark respiration were positively correlated with temperature under nitrate‐limited conditions, but there was no analogous correlation under nutrient‐replete conditions. The results suggest that warmer temperatures and associated more intense thermal stratification of ocean surface waters could lower net photosynthetic rates if the stratification leads to a reduction in the relative growth rates of marine phytoplankton, and at truly supraoptimal temperatures there would likely be a synergistic interaction between the stresses from temperature and high pCO2 (lower pH).

Keywords: Alkalinity, total; Aragonite saturation state; Bicarbonate ion; Biomass/Abundance/Elemental composition; Bottles or small containers/Aquaria (〈20 L); Calcite saturation state; Calculated using seacarb after Nisumaa et al. (2010); Carbon, inorganic, dissolved; Carbon/Chlorophyll a ratio; Carbon/Nitrogen ratio; Carbonate ion; Carbonate system computation flag; Carbon dioxide; Chromista; DATE/TIME; Fugacity of carbon dioxide (water) at sea surface temperature (wet air); Growth/Morphology; Growth rate; Growth rate, standard deviation; Initial slope of the photosynthesis-irradiance curve; Initial slope of the photosynthesis-irradiance curve, standard error; Irradiance; Laboratory experiment; Laboratory strains; Light; Macro-nutrients; Maximum photosynthetic rate (carbon/chlorophyll a); Maximum photosynthetic rate (carbon/chlorophyll a), standard error; Maximum quantum yield of photosystem II; Nitrogen/chlorophyll a ratio; Not applicable; OA-ICC; Ocean Acidification International Coordination Centre; Ochrophyta; Partial pressure of carbon dioxide (water) at sea surface temperature (wet air); Pelagos; pH; Phytoplankton; Primary production/Photosynthesis; Productivity index (carbon/chlorophyll a); Ratio; Registration number of species; Respiration; Salinity; Single species; Species; Temperature; Temperature, water; Thalassiosira pseudonana; Treatment; Type; Uniform resource locator/link to reference

Type: Dataset

Format: text/tab-separated-values, 1763 data points

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

DATA PANGAEA

S·F·X

Fulltext

6

Electronic Resource

The character of adsorption of molecular oxygen(1-) on supported silver surfaces (1978)

Clarkson, R. B. ; McClellan, S.

s.l. : American Chemical Society

The @journal of physical chemistry 〈Washington, DC〉 82 (1978), S. 294-297

add to mindlist on the mindlist

Details

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology , Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1021/j100492a009

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

7

Electronic Resource

Down-Regulation of Bone Marrow Stem Cell Formation by T Cell Subsets Effect of CD8+ Cells on Colony Formation in Peripheral Blood and Bone Marrow (1991)

GAZITT, Y. ; HE, Y-G. ; RIOS, A. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Annals of the New York Academy of Sciences 628 (1991), S. 0

add to mindlist on the mindlist

Details

ISSN: 1749-6632

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Natural Sciences in General

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb17271.x

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

8

Electronic Resource

Heat capacity and turbidity near the critical point of succinonitrile–water (2001)

Nowicki, A. W. ; Ghosh, Madhujit ; McClellan, S. M. ; [et al.]

College Park, Md. : American Institute of Physics (AIP)

The Journal of Chemical Physics 114 (2001), S. 4625-4633

add to mindlist on the mindlist

Details

ISSN: 1089-7690

Source: AIP Digital Archive

Topics: Physics , Chemistry and Pharmacology

Notes: Both the heat capacity and the turbidity of the liquid–liquid mixture succinonitrile–water near its upper critical consolute point were measured and two amplitude relations were tested. Using an adiabatic calorimeter to measure the heat capacity and the transmitted light intensity to determine the turbidity, precise and reproducible data determined the critical exponents α, ν, and γ consistent with theoretical predictions. The correlation length ξ0=0.168±0.004 nm was determined from the turbidity experiment while the heat capacity amplitudes were A+=0.0543±0.0004 J/(cm3 K) in the one- and A−=0.1013±0.0004 J/(cm3 K) in the two-phase region. The amplitude ratio A+/A−=0.536±0.005 was consistent with other experimental determinations in liquid–liquid mixtures or liquid–vapor systems, and with recent theoretical predictions. The two-scale-factor universality ratio X, now consistent among experiments and theories with a value between 0.017 and 0.020, was determined to be 0.0187±0.0013. © 2001 American Institute of Physics.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1063/1.1344613

Permalink