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  • 1
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    Isolation of an active human transposable element (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-12-30
    Description: Two de novo insertions of truncated L1 elements into the factor VIII gene on the X chromosome have been identified that produced hemophilia A. A full-length L1 element that is the likely progenitor of one of these insertions was isolated by its sequence identity to the factor VIII insertion. This L1 element contains two open-reading frames and is one of at least four alleles of a locus on chromosome 22 that has been occupied by an L1 element for at least 6 million years.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dombroski, B A -- Mathias, S L -- Nanthakumar, E -- Scott, A F -- Kazazian, H H Jr -- New York, N.Y. -- Science. 1991 Dec 20;254(5039):1805-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1662412" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Base Sequence ; Chromosomes, Human, Pair 22 ; *DNA Transposable Elements ; Factor VIII/*genetics ; Genome, Human ; Hemophilia A/*genetics ; Humans ; Molecular Sequence Data ; Open Reading Frames ; Restriction Mapping ; Sequence Homology, Nucleic Acid ; X Chromosome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Reverse transcriptase encoded by a human transposable element (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-12-30
    Description: L1 elements are highly repeated mammalian DNA sequences whose structure suggests dispersal by retrotransposition. A consensus L1 element encodes a protein with sequence similarity to known reverse transcriptases. The second open reading frame from the human L1 element L1.2A was expressed as a fusion protein targeted to Ty1 virus-like particles in Saccharomyces cerevisiae and shown to have reverse transcriptase activity. This activity was eliminated by a missense mutation in the highly conserved amino acid motif Y/F-X-D-D. Thus, L1 represents a potential source of the reverse transcriptase activity necessary for dispersion of the many classes of mammalian retroelements.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mathias, S L -- Scott, A F -- Kazazian, H H Jr -- Boeke, J D -- Gabriel, A -- AI00803/AI/NIAID NIH HHS/ -- CA16519/CA/NCI NIH HHS/ -- GM28931/GM/NIGMS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1991 Dec 20;254(5039):1808-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1722352" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Cloning, Molecular ; *DNA Transposable Elements ; Epitopes/analysis ; Humans ; Immunoblotting ; Kinetics ; Molecular Sequence Data ; Oligodeoxyribonucleotides ; Open Reading Frames ; Plasmids ; Polyribonucleotides ; RNA-Directed DNA Polymerase/*genetics/isolation & purification/metabolism ; Recombinant Fusion Proteins/isolation & purification/metabolism ; Saccharomyces cerevisiae/genetics ; Templates, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    DrugCentral: online drug compendium (2017)
    Oxford University Press
    Details
    Publication Date: 2017-01-05
    Description: DrugCentral ( http://drugcentral.org ) is an open-access online drug compendium. DrugCentral integrates structure, bioactivity, regulatory, pharmacologic actions and indications for active pharmaceutical ingredients approved by FDA and other regulatory agencies. Monitoring of regulatory agencies for new drugs approvals ensures the resource is up-to-date. DrugCentral integrates content for active ingredients with pharmaceutical formulations, indexing drugs and drug label annotations, complementing similar resources available online. Its complementarity with other online resources is facilitated by cross referencing to external resources. At the molecular level, DrugCentral bridges drug-target interactions with pharmacological action and indications. The integration with FDA drug labels enables text mining applications for drug adverse events and clinical trial information. Chemical structure overlap between DrugCentral and five online drug resources, and the overlap between DrugCentral FDA-approved drugs and their presence in four different chemical collections, are discussed. DrugCentral can be accessed via the web application or downloaded in relational database format.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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