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  • 1
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    Extended life-span conferred by cotransporter gene mutations in Drosophila (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-12-16
    Description: Aging is genetically determined and environmentally modulated. In a study of longevity in the adult fruit fly, Drosophila melanogaster, we found that five independent P-element insertional mutations in a single gene resulted in a near doubling of the average adult life-span without a decline in fertility or physical activity. Sequence analysis revealed that the product of this gene, named Indy (for I'm not dead yet), is most closely related to a mammalian sodium dicarboxylate cotransporter-a membrane protein that transports Krebs cycle intermediates. Indy was most abundantly expressed in the fat body, midgut, and oenocytes: the principal sites of intermediary metabolism in the fly. Excision of the P element resulted in a reversion to normal life-span. These mutations may create a metabolic state that mimics caloric restriction, which has been shown to extend life-span.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rogina, B -- Reenan, R A -- Nilsen, S P -- Helfand, S L -- AG14532/AG/NIA NIH HHS/ -- AG16667/AG/NIA NIH HHS/ -- R37 AG016667/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2000 Dec 15;290(5499):2137-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington CT 06030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11118146" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/*genetics ; Amino Acid Sequence ; Animals ; Behavior, Animal ; Biological Transport ; Carrier Proteins/chemistry/*genetics/metabolism ; Crosses, Genetic ; DNA Transposable Elements ; *Dicarboxylic Acid Transporters ; Digestive System/metabolism ; *Drosophila Proteins ; Drosophila melanogaster/*genetics/metabolism/physiology ; Energy Intake ; Energy Metabolism ; Fat Body/metabolism ; Female ; Fertility ; Gene Expression ; *Genes, Insect ; Longevity/*genetics ; Male ; Membrane Proteins/chemistry/metabolism ; Molecular Sequence Data ; Mutagenesis, Insertional ; Mutagenesis, Site-Directed ; *Organic Anion Transporters, Sodium-Dependent ; Sense Organs/cytology/metabolism ; Sequence Homology, Amino Acid ; *Symporters
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Neurobiology. Chaperones take flight (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-02-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helfand, Stephen L -- R37 AG016667/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2002 Feb 1;295(5556):809-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA. shelfand@neuron.uchc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11823628" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Disease Models, Animal ; Dopamine/metabolism ; *Drosophila melanogaster/genetics/metabolism ; HSP70 Heat-Shock Proteins/genetics/*metabolism ; Humans ; Lewy Bodies/ultrastructure ; Molecular Chaperones/*metabolism ; Nerve Degeneration ; Nerve Tissue Proteins/chemistry/genetics/*metabolism ; Neurites/ultrastructure ; Neurons/*metabolism/ultrastructure ; Parkinson Disease/metabolism/pathology/therapy ; Parkinsonian Disorders/*metabolism/pathology/therapy ; Protein Folding ; Risk Factors ; Synucleins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rogina, Blanka -- Helfand, Stephen L -- Frankel, Stewart -- R37 AG016667/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2002 Nov 29;298(5599):1745.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12459580" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Animals ; *Caloric Restriction ; Drosophila/enzymology/genetics/*physiology ; *Drosophila Proteins ; Female ; Gene Expression Regulation ; Genes, Insect ; Heterozygote ; Histone Deacetylases/genetics/*metabolism ; Histones/metabolism ; *Longevity ; Male ; Mutation ; Sirtuins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Dietary restriction: standing up for sirtuins (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-08-28
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985480/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985480/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baur, Joseph A -- Chen, Danica -- Chini, Eduardo N -- Chua, Katrin -- Cohen, Haim Y -- de Cabo, Rafael -- Deng, Chuxia -- Dimmeler, Stefanie -- Gius, David -- Guarente, Leonard P -- Helfand, Stephen L -- Imai, Shin-Ichiro -- Itoh, Hiroshi -- Kadowaki, Takashi -- Koya, Daisuke -- Leeuwenburgh, Christiaan -- McBurney, Michael -- Nabeshima, Yo-Ichi -- Neri, Christian -- Oberdoerffer, Philipp -- Pestell, Richard G -- Rogina, Blanka -- Sadoshima, Junichi -- Sartorelli, Vittorio -- Serrano, Manuel -- Sinclair, David A -- Steegborn, Clemens -- Tatar, Marc -- Tissenbaum, Heidi A -- Tong, Qiang -- Tsubota, Kazuo -- Vaquero, Alejandro -- Verdin, Eric -- P01 AG027916/AG/NIA NIH HHS/ -- R00 AG031182/AG/NIA NIH HHS/ -- R01 AG019719/AG/NIA NIH HHS/ -- R01 AG023039/AG/NIA NIH HHS/ -- R01 AG023088/AG/NIA NIH HHS/ -- R01 AG023088-08/AG/NIA NIH HHS/ -- R01 AG024360/AG/NIA NIH HHS/ -- R01 AG028730/AG/NIA NIH HHS/ -- R01 AG028730-05/AG/NIA NIH HHS/ -- R01 HL067724/HL/NHLBI NIH HHS/ -- R01 HL091469/HL/NHLBI NIH HHS/ -- R01 HL102738/HL/NHLBI NIH HHS/ -- R37 AG024360/AG/NIA NIH HHS/ -- Z99 DK999999/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2010 Aug 27;329(5995):1012-3; author reply 1013-4. doi: 10.1126/science.329.5995.1012.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20798296" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/*physiology ; Animals ; *Caloric Restriction ; Humans ; *Longevity ; Signal Transduction ; Sirtuins/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Human Genomics. Sleeping dogs of the genome (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-12-06
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312280/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312280/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorbunova, Vera -- Boeke, Jef D -- Helfand, Stephen L -- Sedivy, John M -- P01 AG047200/AG/NIA NIH HHS/ -- P01AG047200/AG/NIA NIH HHS/ -- P30GM103410/GM/NIGMS NIH HHS/ -- P50 GM107632/GM/NIGMS NIH HHS/ -- P50GM107632/GM/NIGMS NIH HHS/ -- R01 AG024353/AG/NIA NIH HHS/ -- R01 AG027237/AG/NIA NIH HHS/ -- R01AG024353/AG/NIA NIH HHS/ -- R01AG027237/AG/NIA NIH HHS/ -- R37 AG016667/AG/NIA NIH HHS/ -- R37 AG016694/AG/NIA NIH HHS/ -- R37AG016667/AG/NIA NIH HHS/ -- R37AG016694/AG/NIA NIH HHS/ -- T32 AG041688/AG/NIA NIH HHS/ -- T32AG041688/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2014 Dec 5;346(6214):1187-8. doi: 10.1126/science.aaa3177.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Rochester, Rochester, NY 14627, USA. ; Institute for Systems Genetics, New York University Langone Medical Center, New York, NY 10016, USA. ; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA. ; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA. john_sedivy@brown.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25477445" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/*genetics ; Disease/*genetics ; Genetic Variation ; Genome, Human/*genetics ; Genomic Instability ; Genomics ; Humans ; Long Interspersed Nucleotide Elements/genetics/*physiology ; Mutagenesis, Insertional ; RNA, Messenger/genetics ; Ribonucleoproteins/chemistry/metabolism ; Telomere Homeostasis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Cell recognition during neuronal development (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-09-21
    Description: Insect embryos, with their relatively simple nervous systems, provide a model system with which to study the cellular and molecular mechanisms underlying cell recognition during neuronal development. Such an approach can take advantage of the accessible cells of the grasshopper embryo and the accessible genes of Drosophila. The growth cones of identified neurons express selective affinities for specific axonal surfaces; such specificities give rise to the stereotyped patterns of selective fasciculation common to both species. These and other results suggest that early in development cell lineage and cell interactions lead to the differential expression of cell recognition molecules on the surfaces of small subsets of embryonic neurons whose axons selectively fasciculate with one another. Monoclonal antibodies reveal surface molecules in the Drosophila embryo whose expression correlates with this prediction. It should now be possible to isolate the genes encoding these potential cell recognition molecules and to test their function through the use of molecular genetic approaches in Drosophila.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goodman, C S -- Bastiani, M J -- Doe, C Q -- du Lac, S -- Helfand, S L -- Kuwada, J Y -- Thomas, J B -- NS 18366/NS/NINDS NIH HHS/ -- NS 20299/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Sep 21;225(4668):1271-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474176" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal ; Antigens, Surface/analysis ; Axons/physiology ; *Cell Communication ; Drosophila/embryology ; Grasshoppers/embryology ; Insects/*embryology ; Models, Neurological ; Nervous System/*embryology ; Neurons/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Electronic Resource
    Electronic Resource
    Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1 (1983)
    [s.l.] : Nature Publishing Group
    Nature 306 (1983), S. 376-378 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] HNK-1 (Leu 7) is a monoclonal mouse IgM antibody which was produced against a membrane antigen from the cultured T-cell line, HSB-2. HNK-1 recognizes a differentiation antigen present on approximately 15% of normal peripheral blood lymphocytes2,3. These cells are principally large granular ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/306376a0
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    Paper (German National Licenses)
    Fulltext
  • 8
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    Long-lived Indy and calorie restriction interact to extend life span (2009)
    National Academy of Sciences
    Details
    Publication Date: 2009-05-22
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 9
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    Long-lived Indy induces reduced mitochondrial reactive oxygen species production and oxidative damage (2009)
    National Academy of Sciences
    Details
    Publication Date: 2009-01-21
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 10
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    A simple chemosensory response in Drosophila and the isolation of acj mutants in which it is affected. (1989)
    National Academy of Sciences
    Details
    Publication Date: 1989-10-01
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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