Publication Date:
2014-08-30
Description:
Pigment patterns are useful for elucidating fundamental mechanisms of pattern formation and how these mechanisms evolve. In zebrafish, several pigment cell classes interact to generate stripes, yet the developmental requirements and origins of these cells remain poorly understood. Using zebrafish and a related species, we identified roles for thyroid hormone (TH) in pigment cell development and patterning, and in postembryonic development more generally. We show that adult pigment cells arise from distinct lineages having distinct requirements for TH and that differential TH dependence can evolve within lineages. Our findings demonstrate critical functions for TH in determining pigment pattern phenotype and highlight the potential for evolutionary diversification at the intersection of developmental and endocrine mechanisms.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211621/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211621/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McMenamin, Sarah K -- Bain, Emily J -- McCann, Anna E -- Patterson, Larissa B -- Eom, Dae Seok -- Waller, Zachary P -- Hamill, James C -- Kuhlman, Julie A -- Eisen, Judith S -- Parichy, David M -- F32 GM090362/GM/NIGMS NIH HHS/ -- K99 GM105874/GM/NIGMS NIH HHS/ -- P01 HD022486/HD/NICHD NIH HHS/ -- P01 HD22486/HD/NICHD NIH HHS/ -- R01 GM062182/GM/NIGMS NIH HHS/ -- R01 GM096906/GM/NIGMS NIH HHS/ -- R01 GM111233/GM/NIGMS NIH HHS/ -- R03 HD074787/HD/NICHD NIH HHS/ -- T32 HD007183/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2014 Sep 12;345(6202):1358-61. doi: 10.1126/science.1256251. Epub 2014 Aug 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Washington, Seattle, WA 98195, USA. ; Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA. ; Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA. ; Department of Biology, University of Washington, Seattle, WA 98195, USA. Institute for Stem Cell and Regenerative Medicine, UW Medicine Research, Seattle, WA 98109, USA. dparichy@u.washington.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25170046" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Body Patterning
;
*Cell Differentiation
;
*Cell Lineage
;
Embryo, Nonmammalian/cytology
;
Melanophores/cytology/drug effects/*physiology
;
Skin Pigmentation/genetics/*physiology
;
Thyroid Hormones/genetics/pharmacology/*physiology
;
Zebrafish/*embryology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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