ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Magnesium alloys: Ready for the road (2015)
    Springer Nature
    Details
    Publication Date: 2015-11-21
    Description: Nature Materials 14, 1189 (2015). doi:10.1038/nmat4453 Author: Gerald S. Frankel Strength, ductility and corrosion resistance have been simultaneously obtained in a low-density lithium-containing magnesium alloy, thereby enhancing its potential use in transportation.
    Print ISSN: 1476-1122
    Electronic ISSN: 1476-4660
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Natural Sciences in General , Physics
    Published by Springer Nature
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency (2015)
    Oxford University Press
    Details
    Publication Date: 2015-10-23
    Description: Arginase deficiency is caused by deficiency of arginase 1 (ARG1), a urea cycle enzyme that converts arginine to ornithine. Clinical features of arginase deficiency include elevated plasma arginine levels, spastic diplegia, intellectual disability, seizures and growth deficiency. Unlike other urea cycle disorders, recurrent hyperammonemia is typically less severe in this disorder. Normalization of plasma arginine levels is the consensus treatment goal, because elevations of arginine and its metabolites are suspected to contribute to the neurologic features. Using data from patients enrolled in a natural history study conducted by the Urea Cycle Disorders Consortium, we found that 97% of plasma arginine levels in subjects with arginase deficiency were above the normal range despite conventional treatment. Recently, arginine-degrading enzymes have been used to deplete arginine as a therapeutic strategy in cancer. We tested whether one of these enzymes, a pegylated human recombinant arginase 1 (AEB1102), reduces plasma arginine in murine models of arginase deficiency. In neonatal and adult mice with arginase deficiency, AEB1102 reduced the plasma arginine after single and repeated doses. However, survival did not improve likely, because this pegylated enzyme does not enter hepatocytes and does not improve hyperammonemia that accounts for lethality. Although murine models required dosing every 48 h, studies in cynomolgus monkeys indicate that less frequent dosing may be possible in patients. Given that elevated plasma arginine rather than hyperammonemia is the major treatment challenge, we propose that AEB1102 may have therapeutic potential as an arginine-reducing agent in patients with arginase deficiency.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Genetic technologies. Facing inheritable genetic modifications (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-05-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frankel, M S -- Chapman, A R -- New York, N.Y. -- Science. 2001 May 18;292(5520):1303.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Science and Policy Programs, the American Association for the Advancement of Science, Washington, DC 20005, USA. mfrankel@aaas.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11360984" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioethics ; DNA, Mitochondrial/genetics ; Eugenics/*legislation & jurisprudence/trends ; Gene Transfer Techniques/adverse effects ; Genetic Engineering/*legislation & jurisprudence/standards/trends ; Germ-Line Mutation/*genetics ; Government ; *Government Regulation ; Humans ; Private Sector ; Public Sector ; Transgenes/genetics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    In search of stem cell policy (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-03-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frankel, M S -- New York, N.Y. -- Science. 2000 Feb 25;287(5457):1397.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10722382" target="_blank"〉PubMed〈/a〉
    Keywords: Bioethics ; Biomedical Research ; *Embryo Research ; Embryo, Mammalian/*cytology ; Ethical Review ; Humans ; *Public Policy ; *Research ; Social Responsibility ; Social Values ; *Stem Cells ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Public access to data (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-03-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frankel, M S -- New York, N.Y. -- Science. 1999 Feb 19;283(5405):1114.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10075568" target="_blank"〉PubMed〈/a〉
    Keywords: Financing, Government/legislation & jurisprudence ; Information Management/*legislation & jurisprudence ; Intellectual Property ; *Public Policy ; Publishing/*legislation & jurisprudence ; Research/legislation & jurisprudence ; Research Support as Topic/*legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    Regulating the boundaries of dual-use research (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-23
    Description: A new U.S. policy for dual-use life science research defines what is permissible by scientists and the government. However, further negotiations will be needed as governments realize the consequences of such boundaries for research and society.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frankel, Mark S -- New York, N.Y. -- Science. 2012 Jun 22;336(6088):1523-5. doi: 10.1126/science.1221285.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program on Scientific Responsibility, Human Rights and Law, American Association for the Advancement of Science, Washington, DC 20005, USA. mfrankel@aaas.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22723408" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; Animals ; Biomedical Research/*legislation & jurisprudence ; Financing, Government ; *Government Regulation ; Humans ; Influenza A Virus, H5N1 Subtype ; Information Dissemination ; International Cooperation ; *Public Policy ; *Publishing ; Research Support as Topic ; Security Measures ; United States ; United States Government Agencies
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Using ethics to fight bioterrorism (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-08-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frankel, Mark S -- New York, N.Y. -- Science. 2005 Aug 12;309(5737):1012-7; author reply 1012-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16099963" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Science Disciplines ; Bioterrorism/*prevention & control ; *Codes of Ethics ; *Ethics, Research ; Research Personnel/*ethics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rogina, Blanka -- Helfand, Stephen L -- Frankel, Stewart -- R37 AG016667/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2002 Nov 29;298(5599):1745.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12459580" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Animals ; *Caloric Restriction ; Drosophila/enzymology/genetics/*physiology ; *Drosophila Proteins ; Female ; Gene Expression Regulation ; Genes, Insect ; Heterozygote ; Histone Deacetylases/genetics/*metabolism ; Histones/metabolism ; *Longevity ; Male ; Mutation ; Sirtuins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Replication of HIV-1 in dendritic cell-derived syncytia at the mucosal surface of the adenoid (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-04-05
    Description: Human immunodeficiency virus-type 1 (HIV-1) replicates actively in infected individuals, yet cells with intracellular depots of viral protein are observed only infrequently. Many cells expressing the HIV-1 Gag protein were detected at the surface of the nasopharyngeal tonsil or adenoid. This infected mucosal surface contained T cells and dendritic cells, two cell types that together support HIV-1 replication in culture. The infected cells were multinucleated syncytia and expressed the S100 and p55 dendritic cell markers. Eleven of the 13 specimens analyzed were from donors who did not have symptoms of acquired immunodeficiency syndrome (AIDS). The interaction of dendritic cells and T cells in mucosa may support HIV-1 replication, even in subclinical stages of infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frankel, S S -- Wenig, B M -- Burke, A P -- Mannan, P -- Thompson, L D -- Abbondanzo, S L -- Nelson, A M -- Pope, M -- Steinman, R M -- AI24775/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1996 Apr 5;272(5258):115-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉AIDS Division, Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington DC 20306-6000, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8600520" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoids/chemistry/*virology ; Adult ; Dendritic Cells/physiology/*virology ; Female ; Germinal Center/chemistry/virology ; Giant Cells/*virology ; HIV Core Protein p24/analysis ; HIV Infections/*virology ; HIV-1/*physiology ; Humans ; In Situ Hybridization ; Keratins/analysis ; Male ; Mucous Membrane/chemistry/virology ; T-Lymphocytes/physiology ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Biosecurity. Educating scientists about dual use (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-12-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sta Ana, Jennifer L -- Frankel, Mark S -- Berger, Kavita M -- New York, N.Y. -- Science. 2009 Nov 27;326(5957):1193. doi: 10.1126/science.1176127.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program on Scientific Freedom, Responsibility, and Law, American Association for the Advancement of Science (AAAS), Washington, DC 20005, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965453" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Science Disciplines/*education ; Biological Warfare Agents ; *Biomedical Research ; Education/economics ; Medical Laboratory Personnel/*education ; Research Personnel/*education ; *Security Measures/legislation & jurisprudence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...