Publication Date:
1980-08-08
Description:
Quantitative neurohistological techniques were used to examine the hippocampal complex of laboratory rats maintained on ethanol-containing or control diets for 5 months followed by a 2-month alcohol-free period. Chronic ethanol consumption resulted in a significant loss of hippocampal pyramidal and dentate gyrus granule cells. This study provides direct evidence that long-term ethanol consumption, in the absence of malnutrition, produces neuronal loss in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walker, D W -- Barnes, D E -- Zornetzer, S F -- Hunter, B E -- Kubanis, P -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):711-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394532" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Ethanol/*pharmacology
;
Hippocampus/drug effects/*physiology
;
Male
;
Neurons/drug effects/*physiology
;
Pyramidal Tracts/drug effects/physiology
;
Rats
;
Time Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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