Publication Date:
1993-04-23
Description:
Development of the appropriate CD4+ T helper (TH) subset during an immune response is important for disease resolution. With the use of naive, ovalbumin-specific alpha beta T cell receptor transgenic T cell, it was found that heat-killed Listeria monocytogenes induced TH1 development in vitro through macrophage production of interleukin-12 (IL-12). Moreover, inhibition of macrophage production of IL-12 may explain the ability of IL-10 to suppress TH1 development. Murine immune responses to L. monocytogenes in vivo are of the appropriate TH1 phenotype. Therefore, this regulatory pathway may have evolved to enable innate immune cells, through interactions with microbial pathogens, to direct development of specific immunity toward the appropriate TH phenotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsieh, C S -- Macatonia, S E -- Tripp, C S -- Wolf, S F -- O'Garra, A -- Murphy, K M -- 1 PO1 A131238-01/PHS HHS/ -- 5 T32 GM07200-17/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1993 Apr 23;260(5107):547-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8097338" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
CD4-Positive T-Lymphocytes/cytology/*immunology
;
Cell Differentiation
;
Cells, Cultured
;
Interferon-gamma/secretion
;
Interleukin-10/pharmacology
;
Interleukin-12
;
Interleukin-2/biosynthesis
;
Interleukins/biosynthesis/*immunology/pharmacology
;
Listeria monocytogenes/*immunology
;
Macrophages/*immunology
;
Mice
;
Mice, Transgenic
;
Phenotype
;
Receptors, Antigen, T-Cell, alpha-beta/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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