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  • 1
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    A glimmer of light for neuropsychiatric disorders (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-10-17
    Description: Understanding the pathogenesis of neuropsychiatric disorders is a substantial challenge for neurobiologists. It has long been hoped that identifying alleles that confer increased risk of such disorders would provide clues for neurobiological investigation. But this quest has been stymied by a lack of validated biological markers for characterizing and distinguishing the different disorders and by the genetic complexity underpinning these diseases. Now, modern genomic technologies have begun to facilitate the discovery of relevant genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hyman, Steven E -- England -- Nature. 2008 Oct 16;455(7215):890-3. doi: 10.1038/nature07454.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Office of the Provost, Harvard University, Department of Neurobiology, Harvard Medical School, Massachusetts Hall, Cambridge, Massachusetts 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18923510" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Mental Disorders/diagnosis/epidemiology/genetics/physiopathology ; *Nervous System Diseases/diagnosis/epidemiology/genetics/physiopathology ; Phenotype
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Medicine. What are the right targets for psychopharmacology? (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-01-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hyman, Steven E -- Fenton, Wayne S -- New York, N.Y. -- Science. 2003 Jan 17;299(5605):350-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Harvard University, Boston, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12532001" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Clinical Trials as Topic ; *Cognition/drug effects ; Cognition Disorders/drug therapy/etiology ; Consensus Development Conferences, NIH as Topic ; Humans ; Mental Disorders/classification/diagnosis/*drug therapy/physiopathology ; National Institute of Mental Health (U.S.) ; *Psychopharmacology ; Psychotropic Drugs/*therapeutic use ; Schizophrenia/classification/diagnosis/*drug therapy/physiopathology ; Schizophrenic Psychology ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    DARPP-32: regulator of the efficacy of dopaminergic neurotransmission (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-08-07
    Description: Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fienberg, A A -- Hiroi, N -- Mermelstein, P G -- Song, W -- Snyder, G L -- Nishi, A -- Cheramy, A -- O'Callaghan, J P -- Miller, D B -- Cole, D G -- Corbett, R -- Haile, C N -- Cooper, D C -- Onn, S P -- Grace, A A -- Ouimet, C C -- White, F J -- Hyman, S E -- Surmeier, D J -- Girault, J -- Nestler, E J -- Greengard, P -- DA 08227/DA/NIDA NIH HHS/ -- DA10044/DA/NIDA NIH HHS/ -- F31 DA005794/DA/NIDA NIH HHS/ -- MH40899/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1998 Aug 7;281(5378):838-42.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9694658" target="_blank"〉PubMed〈/a〉
    Keywords: Amphetamines/pharmacology ; Animals ; Behavior, Animal/drug effects ; Calcium/metabolism ; Cocaine/pharmacology ; Corpus Striatum/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Dopamine/pharmacology/*physiology ; Dopamine Agents/pharmacology ; Dopamine and cAMP-Regulated Phosphoprotein 32 ; Female ; Gene Expression Regulation ; Gene Targeting ; Genes, fos ; Glutamic Acid/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Nerve Tissue Proteins/genetics/*metabolism ; Neurons/*metabolism ; Phosphoprotein Phosphatases/metabolism ; *Phosphoproteins ; Phosphorylation ; Raclopride ; Receptors, Dopamine D1/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Salicylamides/pharmacology ; Sodium-Potassium-Exchanging ATPase/metabolism ; *Synaptic Transmission ; gamma-Aminobutyric Acid/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Grand challenges in global mental health (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-07-08
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173804/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173804/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collins, Pamela Y -- Patel, Vikram -- Joestl, Sarah S -- March, Dana -- Insel, Thomas R -- Daar, Abdallah S -- Scientific Advisory Board and the Executive Committee of the Grand Challenges on Global Mental Health -- Anderson, Warwick -- Dhansay, Muhammad A -- Phillips, Anthony -- Shurin, Susan -- Walport, Mark -- Ewart, Wendy -- Savill, Sir John -- Bordin, Isabel A -- Costello, E Jane -- Durkin, Maureen -- Fairburn, Christopher -- Glass, Roger I -- Hall, Wayne -- Huang, Yueqin -- Hyman, Steven E -- Jamison, Kay -- Kaaya, Sylvia -- Kapur, Shitij -- Kleinman, Arthur -- Ogunniyi, Adesola -- Otero-Ojeda, Angel -- Poo, Mu-Ming -- Ravindranath, Vijayalakshmi -- Sahakian, Barbara J -- Saxena, Shekhar -- Singer, Peter A -- Stein, Dan J -- 079113/Wellcome Trust/United Kingdom -- 091834/Wellcome Trust/United Kingdom -- P30 HD003352/HD/NICHD NIH HHS/ -- Z99 MH999999/Intramural NIH HHS/ -- England -- Nature. 2011 Jul 6;475(7354):27-30. doi: 10.1038/475027a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Office for Research on Disparities and Global Mental Health, National Institute of Mental Health, Maryland, USA. pamela.collins@nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21734685" target="_blank"〉PubMed〈/a〉
    Keywords: *Global Health ; Humans ; Mental Disorders/economics/epidemiology/prevention & control ; Mental Health/*statistics & numerical data ; Substance-Related Disorders/economics/epidemiology ; World Health Organization
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Perspective: Revealing molecular secrets (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-04-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hyman, Steven E -- England -- Nature. 2014 Apr 3;508(7494):S20. doi: 10.1038/508S20a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stanley Center for Psychiatric Research at the Broad Institute of Harvard and Massachusetts Institute of Technology in Cambridge, Massachusetts. He is a former director of the US National Institute of Mental Health.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24695333" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA Copy Number Variations/genetics ; Disease Models, Animal ; Humans ; Models, Genetic ; Multifactorial Inheritance/genetics ; Schizophrenia/drug therapy/*genetics ; Translational Medical Research/methods/*trends
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    Shaking out the cause of addiction (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-08-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hyman, S E -- New York, N.Y. -- Science. 1996 Aug 2;273(5275):611-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institute of Mental Health, Rockville, MD 20857, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8701316" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cyclic AMP/metabolism ; Cyclic AMP Response Element-Binding Protein/genetics/*physiology ; Drug Tolerance ; Locus Coeruleus/metabolism/physiology ; Mice ; Mice, Knockout ; Narcotics/*administration & dosage/adverse effects/pharmacology ; Neuronal Plasticity ; Neurons/physiology ; Opioid-Related Disorders/*etiology/metabolism ; Receptors, Opioid, mu/metabolism ; Signal Transduction ; Substance Withdrawal Syndrome/etiology/metabolism ; Up-Regulation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Genome-sequencing anniversary. The meaning of the Human Genome Project for neuropsychiatric disorders (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hyman, Steven E -- New York, N.Y. -- Science. 2011 Feb 25;331(6020):1026. doi: 10.1126/science.1203544.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Harvard University, MA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21350167" target="_blank"〉PubMed〈/a〉
    Keywords: Brain/*physiology/physiopathology ; *Human Genome Project ; Humans ; Mental Disorders/*genetics/physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Time for new schizophrenia Rx (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-03-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hyman, Steven E -- New York, N.Y. -- Science. 2014 Mar 14;343(6176):1177. doi: 10.1126/science.1252603.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Steven E. Hyman is director of the Stanley Center for Psychiatric Research at the Broad Institute of Harvard and the Massachusetts Institute of Technology in Cambridge, MA, and a professor in the Department of Stem Cell and Regenerative Biology at Harvard University, Cambridge, MA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24626901" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/drug therapy ; Antipsychotic Agents/adverse effects/*therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Diabetes Mellitus, Type 2/drug therapy ; *Drug Discovery ; Drug Industry/trends ; Drug Prescriptions ; Humans ; International Cooperation ; Lupus Erythematosus, Systemic/drug therapy ; National Institutes of Health (U.S.) ; Schizophrenia/*drug therapy/genetics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Protect researchers from harassment (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-06-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hyman, Steven E -- Goldberg, Michael E -- New York, N.Y. -- Science. 2015 Jun 12;348(6240):1216-7. doi: 10.1126/science.348.6240.1216-c.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉President, Society for Neuroscience. Broad Institute, Cambridge, MA 02142-1403, USA. media@sfn.org. ; Chair, Society for Neuroscience Committee on Animals in Research. Columbia University, New York, NY 10032-1007, USA. media@sfn.org.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26068840" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Experimentation/*ethics ; Animal Rights ; Animals ; Humans ; Neurosciences/*ethics ; Pan troglodytes ; *Research Personnel ; Social Behavior ; Violence/*prevention & control
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Ciliary neurotrophic factor coordinately activates transcription of neuropeptide genes in a neuroblastoma cell line. (1993)
    National Academy of Sciences
    Details
    Publication Date: 1993-01-15
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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