Publication Date:
2000-03-24
Description:
Correct positioning of the mitotic spindle is critical for cell division and development. Spindle positioning involves a search-and-capture mechanism whereby dynamic microtubules find and then interact with specific sites on the submembrane cortex. Genetic, biochemical, and imaging experiments suggest a mechanism for cortical-microtubule capture. Bim1p, located at microtubule distal ends, bound Kar9p, a protein associated with the daughter cell cortex. Bim1p is the yeast ortholog of human EB1, a binding partner for the adenomatous polyposis coli tumor suppressor. EB1 family proteins may have a general role in linking the microtubule cytoskeleton to cortical polarity determinants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, L -- Tirnauer, J S -- Li, J -- Schuyler, S C -- Liu, J Y -- Pellman, D -- GM55772/GM/NIGMS NIH HHS/ -- KO8 DK02578/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2000 Mar 24;287(5461):2260-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Pediatric Oncology, The Dana-Farber Cancer Institute, and Pediatric Hematology, The Children's Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10731147" target="_blank"〉PubMed〈/a〉
Keywords:
Adenomatous Polyposis Coli Protein
;
Binding Sites
;
Cell Cycle
;
Cell Cycle Proteins/genetics/*metabolism
;
Cytoskeletal Proteins/metabolism
;
G1 Phase
;
Microtubule Proteins/genetics/*metabolism
;
Microtubule-Associated Proteins/metabolism
;
Microtubules/*metabolism
;
Nuclear Proteins/genetics/*metabolism
;
Protein Binding
;
Recombinant Fusion Proteins/metabolism
;
Saccharomyces cerevisiae/cytology/genetics/*physiology
;
*Saccharomyces cerevisiae Proteins
;
Spindle Apparatus/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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