Publication Date:
2010-10-12
Description:
Most hosts, including humans, are simultaneously or sequentially infected with several parasites. A key question is whether patterns of coinfection arise because infection by one parasite species affects susceptibility to others or because of inherent differences between hosts. We used time-series data from individual hosts in natural populations to analyze patterns of infection risk for a microparasite community, detecting large positive and negative effects of other infections. Patterns remain once variations in host susceptibility and exposure are accounted for. Indeed, effects are typically of greater magnitude, and explain more variation in infection risk, than the effects associated with host and environmental factors more commonly considered in disease studies. We highlight the danger of mistaken inference when considering parasite species in isolation rather than parasite communities.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033556/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033556/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Telfer, Sandra -- Lambin, Xavier -- Birtles, Richard -- Beldomenico, Pablo -- Burthe, Sarah -- Paterson, Steve -- Begon, Mike -- 070675/Z/03/Z/Wellcome Trust/United Kingdom -- 075202/Wellcome Trust/United Kingdom -- 075202/Z/04/Z/Wellcome Trust/United Kingdom -- 081705/Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2010 Oct 8;330(6001):243-6. doi: 10.1126/science.1190333.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK. s.telfer@abdn.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20929776" target="_blank"〉PubMed〈/a〉
Keywords:
Anaplasma phagocytophilum/physiology
;
Animals
;
Animals, Wild/microbiology/parasitology/virology
;
*Arvicolinae/microbiology/parasitology/virology
;
Babesia microti
;
Babesiosis/complications/immunology/parasitology/*veterinary
;
Bartonella/physiology
;
Bartonella Infections/complications/immunology/microbiology/*veterinary
;
Cowpox/complications/immunology/*veterinary/virology
;
Disease Susceptibility
;
Ehrlichiosis/complications/immunology/microbiology/*veterinary
;
Female
;
Host-Pathogen Interactions
;
Male
;
*Microbial Interactions
;
Risk Factors
;
*Rodent Diseases/microbiology/parasitology/virology
;
Seasons
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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