Publication Date:
2008-06-17
Description:
Differentiation and secondary metabolism are correlated processes in fungi that respond to light. In Aspergillus nidulans, light inhibits sexual reproduction as well as secondary metabolism. We identified the heterotrimeric velvet complex VelB/VeA/LaeA connecting light-responding developmental regulation and control of secondary metabolism. VeA, which is primarily expressed in the dark, physically interacts with VelB, which is expressed during sexual development. VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either velB or veA results in defects in both sexual fruiting-body formation and the production of secondary metabolites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bayram, Ozgur -- Krappmann, Sven -- Ni, Min -- Bok, Jin Woo -- Helmstaedt, Kerstin -- Valerius, Oliver -- Braus-Stromeyer, Susanna -- Kwon, Nak-Jung -- Keller, Nancy P -- Yu, Jae-Hyuk -- Braus, Gerhard H -- New York, N.Y. -- Science. 2008 Jun 13;320(5882):1504-6. doi: 10.1126/science.1155888.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Microbiology and Genetics, Georg August University, D-37077 Gottingen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18556559" target="_blank"〉PubMed〈/a〉
Keywords:
Active Transport, Cell Nucleus
;
Aspergillus nidulans/genetics/growth & development/*metabolism/physiology
;
Cell Nucleus/*metabolism
;
Cytoplasm/metabolism
;
Darkness
;
Epigenesis, Genetic
;
Fungal Proteins/chemistry/genetics/*metabolism
;
Gene Expression Regulation, Fungal
;
*Light
;
Protein Binding
;
Protein Interaction Mapping
;
Recombinant Fusion Proteins/metabolism
;
Spores, Fungal/physiology
;
Sterigmatocystin/*biosynthesis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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