Publication Date:
2011-12-17
Description:
Most complex multicellular organisms develop clonally from a single cell. This should limit conflicts between cell lineages that could threaten the extensive cooperation of cells within multicellular bodies. Cellular composition can be manipulated in the social amoeba Dictyostelium discoideum, which allows us to test and confirm the two key predictions of this theory. Experimental evolution at low relatedness favored cheating mutants that could destroy multicellular development. However, under high relatedness, the forces of mutation and within-individual selection are too small for these destructive cheaters to spread, as shown by a mutation accumulation experiment. Thus, we conclude that the single-cell bottleneck is a powerful stabilizer of cellular cooperation in multicellular organisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuzdzal-Fick, Jennie J -- Fox, Sara A -- Strassmann, Joan E -- Queller, David C -- New York, N.Y. -- Science. 2011 Dec 16;334(6062):1548-51. doi: 10.1126/science.1213272.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Rice University, Houston, TX 77005, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22174251" target="_blank"〉PubMed〈/a〉
Keywords:
*Biological Evolution
;
Clone Cells/cytology
;
Dictyostelium/*cytology/genetics/*physiology
;
Models, Biological
;
Mutation
;
Reproduction
;
Spores, Protozoan
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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