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  • 1
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    Herbivore diet changes in East Africa [Ecology] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-09-16
    Description: A large stable isotope dataset from East and Central Africa from ca. 30 regional collection sites that range from forest to grassland shows that most extant East and Central African large herbivore taxa have diets dominated by C4 grazing or C3 browsing. Comparison with the fossil record shows that faunal...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    First-principles and spectroscopic studies of Bi(110) films: Thickness-dependent Dirac modes and property oscillations (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-11-08
    Description: Author(s): G. Bian, X. Wang, T. Miller, T.-C. Chiang, P. J. Kowalczyk, O. Mahapatra, and S. A. Brown The electronic structure of Bi(110) thin films as a function of film thickness is investigated by first-principles calculations, angle-resolved photoemission spectroscopy, and scanning tunneling microscopy. Energy minimization in the calculation reveals significant atomic relaxation and rebonding at... [Phys. Rev. B 90, 195409] Published Fri Nov 07, 2014
    Keywords: Surface physics, nanoscale physics, low-dimensional systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
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    Origin of the moiré pattern in thin Bi films deposited on HOPG (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-01-29
    Description: Author(s): P. J. Kowalczyk, O. Mahapatra, D. Belić, S. A. Brown, G. Bian, and T.-C. Chiang Thin Bi(110) films deposited on highly oriented pyrolytic graphite (HOPG) exhibit a pronounced moiré pattern; here the origin of the moiré pattern is investigated using scanning tunneling microscopy (STM) and spectroscopy (STS), high-resolution transmission electron microscopy (HR-TEM), and density ... [Phys. Rev. B 91, 045434] Published Wed Jan 28, 2015
    Keywords: Surface physics, nanoscale physics, low-dimensional systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    Serum factors in older individuals change cellular clock properties [Neuroscience] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-04-27
    Description: Human aging is accompanied by dramatic changes in daily sleep–wake behavior: Activity shifts to an earlier phase, and the consolidation of sleep and wake is disturbed. Although this daily circadian rhythm is brain-controlled, its mechanism is encoded by cell-autonomous circadian clocks functioning in nearly every cell of the body. In fact, human clock properties measured in peripheral cells such as fibroblasts closely mimic those measured physiologically and behaviorally in the same subjects. To understand better the molecular mechanisms by which human aging affects circadian clocks, we characterized the clock properties of fibroblasts cultivated from dermal biopsies of young and older subjects. Fibroblast period length, amplitude, and phase were identical in the two groups even though behavior was not, thereby suggesting that basic clock properties of peripheral cells do not change during aging. Interestingly, measurement of the same cells in the presence of human serum from older donors shortened period length and advanced the phase of cellular circadian rhythms compared with treatment with serum from young subjects, indicating that a circulating factor might alter human chronotype. Further experiments demonstrated that this effect is caused by a thermolabile factor present in serum of older individuals. Thus, even though the molecular machinery of peripheral circadian clocks does not change with age, some age-related circadian dysfunction observed in vivo might be of hormonal origin and therefore might be pharmacologically remediable.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 5
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    Circadian rhythms. Chronobiology--reducing time (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-07-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schibler, U -- Ripperger, J A -- Brown, S A -- New York, N.Y. -- Science. 2001 Jul 20;293(5529):437-8. Epub 2001 Jul 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Sciences II, University of Geneva, CH-1211 Geneva 4, Switzerland. ueli.schibler@molbio.unige.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11441150" target="_blank"〉PubMed〈/a〉
    Keywords: ARNTL Transcription Factors ; Animals ; Basic Helix-Loop-Helix Transcription Factors ; Biological Clocks/*physiology ; CLOCK Proteins ; Cell Cycle Proteins ; Circadian Rhythm/*physiology ; Cryptochromes ; DNA/metabolism ; Dimerization ; *Drosophila Proteins ; Electron Transport ; *Eye Proteins ; Feedback ; Flavoproteins/metabolism ; Mice ; NAD/*metabolism ; Nerve Tissue Proteins/genetics/*metabolism ; Nuclear Proteins/metabolism ; Oxidation-Reduction ; Period Circadian Proteins ; *Photoreceptor Cells, Invertebrate ; Prosencephalon/metabolism ; Receptors, G-Protein-Coupled ; Suprachiasmatic Nucleus/physiology ; Trans-Activators/*metabolism ; Transcription Factors/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Resetting of circadian time in peripheral tissues by glucocorticoid signaling (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-09-29
    Description: In mammals, circadian oscillators reside not only in the suprachiasmatic nucleus of the brain, which harbors the central pacemaker, but also in most peripheral tissues. Here, we show that the glucocorticoid hormone analog dexamethasone induces circadian gene expression in cultured rat-1 fibroblasts and transiently changes the phase of circadian gene expression in liver, kidney, and heart. However, dexamethasone does not affect cyclic gene expression in neurons of the suprachiasmatic nucleus. This enabled us to establish an apparent phase-shift response curve specifically for peripheral clocks in intact animals. In contrast to the central clock, circadian oscillators in peripheral tissues appear to remain responsive to phase resetting throughout the day.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balsalobre, A -- Brown, S A -- Marcacci, L -- Tronche, F -- Kellendonk, C -- Reichardt, H M -- Schutz, G -- Schibler, U -- New York, N.Y. -- Science. 2000 Sep 29;289(5488):2344-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departement de Biologie Moleculaire, Sciences II, Universite de Geneve, 30 Quai Ernest Ansermet, CH-1211 Geneve, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11009419" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Clocks/*physiology ; Cell Cycle Proteins ; Cell Line ; Circadian Rhythm/*physiology ; *DNA-Binding Proteins ; Dexamethasone/analogs & derivatives/*pharmacology ; Female ; *Gene Expression Regulation/drug effects ; Kidney/metabolism ; Liver/metabolism ; Male ; Mice ; Mice, Inbred Strains ; Mutation ; Myocardium/metabolism ; Neurons/metabolism ; Nuclear Proteins/genetics/metabolism ; Period Circadian Proteins ; Rats ; Receptors, Glucocorticoid/genetics/metabolism ; *Signal Transduction ; Suprachiasmatic Nucleus/metabolism ; Transcription Factors/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-04-30
    Description: The clock proteins PERIOD1 (PER1) and PERIOD2 (PER2) play essential roles in a negative transcriptional feedback loop that generates circadian rhythms in mammalian cells. We identified two PER1-associated factors, NONO and WDR5, that modulate PER activity. The reduction of NONO expression by RNA interference (RNAi) attenuated circadian rhythms in mammalian cells, and fruit flies carrying a hypomorphic allele were nearly arrhythmic. WDR5, a subunit of histone methyltransferase complexes, augmented PER-mediated transcriptional repression, and its reduction by RNAi diminished circadian histone methylations at the promoter of a clock gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, Steven A -- Ripperger, Juergen -- Kadener, Sebastian -- Fleury-Olela, Fabienne -- Vilbois, Francis -- Rosbash, Michael -- Schibler, Ueli -- New York, N.Y. -- Science. 2005 Apr 29;308(5722):693-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology and National Centres of Competence in Research (NCCR) Frontiers in Genetics, Sciences III, University of Geneva, 30 Quai Ernest Ansermet, CH-1211 Geneva-4, Switzerland. steven.brown@molbio.unige.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15860628" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Animals ; Carrier Proteins/genetics/*metabolism ; Cell Cycle Proteins ; Cell Line ; *Circadian Rhythm ; DNA-Binding Proteins/genetics/metabolism ; Drosophila/genetics/physiology ; Drosophila Proteins/genetics/physiology ; Female ; Gene Expression Regulation ; Histones/metabolism ; Immunoprecipitation ; Male ; Methylation ; Mice ; Mice, Inbred BALB C ; Nuclear Proteins/genetics/*metabolism/physiology ; Nuclear Receptor Subfamily 1, Group D, Member 1 ; Period Circadian Proteins ; Promoter Regions, Genetic ; Proteins/genetics/*metabolism ; RNA Interference ; Rats ; Receptors, Cytoplasmic and Nuclear/genetics/metabolism ; Transcription Factors ; Transcription, Genetic ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Circadian rhythms. A new histone code for clocks? (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, Steven A -- New York, N.Y. -- Science. 2011 Sep 30;333(6051):1833-4. doi: 10.1126/science.1212842.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Pharmacology and Toxicology, University of Zurich, Zurich 8057, Switzerland. steven.brown@pharma.uzh.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21960618" target="_blank"〉PubMed〈/a〉
    Keywords: ARNTL Transcription Factors/*metabolism ; Animals ; CLOCK Proteins/*metabolism ; *Circadian Clocks ; DNA-Binding Proteins ; Humans ; Jumonji Domain-Containing Histone Demethylases ; Male ; Retinoblastoma-Binding Protein 2/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Single atomic layer allotrope of bismuth with rectangular symmetry (2017)
    American Physical Society (APS)
    Details
    Publication Date: 2017-11-28
    Description: Author(s): P. J. Kowalczyk, O. Mahapatra, M. Le Ster, S. A. Brown, G. Bian, X. Wang, and T.-C. Chiang We report the observation of a new allotrope of two-dimensional bismuth. Our scanning tunneling microscopy experiments show that the structure is clearly different than the previously synthesized allotropes β - and α -bismuthene. It has a rectangular symmetry similar to that of α -bismuthene, but is co... [Phys. Rev. B 96, 205434] Published Mon Nov 27, 2017
    Keywords: Surface physics, nanoscale physics, low-dimensional systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 10
    Electronic Resource
    Electronic Resource
    Proton NMR study of effects of synergistic anion and metal ion binding on pH titration of the histidinyl side-chain residues of the half-molecules of ovotransferrin (1987)
    s.l. : American Chemical Society
    Biochemistry 26 (1987), S. 3115-3120 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00385a025
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    Paper (German National Licenses)
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